Granted, there were only a few responses. I've talked with other people experienced with pemoline before & after but I don't have records of these conversations & others I may not link to (deep web board, and it's offline afaik now). You might be entirely right that people respond very differently to the drugs (as they do) and some will get less positive reactions or respond better to e.g. Mephedrone.
There was the russian stimulant mesocarb / sidnocarb that has been speculated to be a prodrug to an oxazoline / pemoline relative. It, too, was reported here on BL by some experienced users to not have the amphetamine-associated rebound & typical tolerance but working even in severely sleep deprived individuals etc. - at the price of leading into straight psychosis instead.
https://www.reddit.com/r/Nootropics...ct_of_sidnocarb_on_learning_and_memory_biull/
http://www.bluelight.org/vb/threads...socarb-(dopaminergic)?p=13264469#post13264469
Glutamate is not the
only mechanism of tolerance of course, but it is a
major involved pathway. Inhibiting NMDA alleviates tolerance to
dopaminergics,
to opioids & possibly even to
GABAergics.
Edit: Yeah, I don't get it who and why decides which RC compounds to synthesize and which ones not. Honestly, I came to to the conclusion - together with others here on BL - that these people behind actually often don't know or don't care much about the pharmacology & science. They are just about the money. It's probably that simple. The NBOMe compounds & bromo-dragonfly were examples of course when they did something terribly wrong. But there is no reason either why next to none of the opioid RCs get marketed publicly, they would sell like nothing with all the opioid addicts desperately looking for a cheap, potent substitute - but probably even the capitalists fear of the epidemic that would cause eventually... They have pushed that mexedrone thing lately, synthesized tons of the stuff, made major campaigns etc. - when it is inactive
and they knew it before.
There would have been uncounted completely legal compounds to sell that would actually work, like the oxazolines, or also MXE derivates, and so on ... if you read in NSPD here from time to time, you'll get stunned what actually is possible in neuroscience / chemistry ... I am no expert by any way, but we have truly intelligent individuals posting here that know what they are talking about. If I'm right, methoxetamine has showed up first on bluelight.
Another interesting thing is that many of the serotonergic stimulants have the risk of pulmonary hypertension & heart valve damage through excessive peripheral 5-HT2B activity. This is especially pronounced with the aminorex derivates but probably also a risk with methylone / 5-/6-APB etc. There are quite some only peripherally active
5-HT2B antagonists known from science that would readily minimize or prevent that damage. Nobody cares to synthesize, sell or ask for them. I've tried to get two major and well known UK vendors into synthesize one of them and some oxazolines. They did not want to do.
I've found someone with robust chemistry skills seriously interested in the aminorex family some day in 2013 or so. He did numerous tries to synthesize 4-MAR but failed to do so- the synthesis seems to be somewhat difficult. I know too less about chemistry to really say something about that..