This is an area of considerable interest for me actually. I was interested in the increases in blood volume and cerebral blood flow that are induced by xenon. Because in me/cfs, pots, and various types of orthostatic intolerance, the overall blood volume and the cerebral blood flow is low.
Heres one source on that
https://www.google.com/url?sa=t&sou...FjACegQICxAB&usg=AOvVaw2swLkKMBB95UVDNmwaHCMH
Hope that link works. If not will edit this post later. Regardless the basics are nobody knows what causes the low blood volume in me/cfs but saline infusions, bloodinfusions, florinef, desmopressin, and strong compression garments have often relieved it, if only temporarily. However its low total blood volume but not anemia, the portion of red blood cells in the blood isnormal, just total low volume with normal proportions of plasma and rbc etc. So not absolutely sure that increasing epo is good. However as I read all these sources it's not confirmed it increases epo. It just increases hif-a 1 or something upstream of epo. Athletes use it to increase blood volume and presumably epo, but athletes do lots of experimental stuff so who knows. What is confirmed is that it increases cerebral blood flow.
Back to me/cfs and blood volume for a second. What is particularly interesting is that there is a major subset of patients that have high blood pressure but low volume, hypovolemic hypertension, so the pressure actually decreases when they get saline or volume expanders which is very counterintuitive. But anyway I'm in I'm subset and often have hyperadrenergic states where I have high pressure or slightly high, and sinus tachycardia as well as pots. Ketamine helps with pain but it absolutely doesnt help with that, if anything it is noticeably sympathomimetic. So when I tried xenon it was nice to notice that it didnt raise my heart rate or give me any type of peripheral overstimulation, if anything it made me noticeably physically calmer.
Anyway in terms of subjective effects, xenon definitely helps my cognition and energy and orthostatic intolerance in a way saline and other volume expanding things do. And this effect isnt extremely long lasting , but it lasts longer than the xenon is in my system, especially if I have many repeated doses. So it's no miracle drug, but that is a great thing it does on top of the really intense pain relief. I will write a blog post with references about this sometime.
Anywsy, yes it doesn't cure me or last that long but nothing does... bc I am severely ill, and the upstream cause is most likely my cervicomedullary syndrome/cci, which need to be address surgically. If I try xenon after this, I'm sure it will speed my recovery and have increasingly long lasting benefits. I think for a more mildly ill person it could have long lasting benefits
pubs.asahq.org
"Nitrogen narcosis" obviously is a known phenomenon experienced by deep sea divers, although nitrogen is not narcotic at standard atmospheric pressure. But perhaps it would be in an artificially pressurised but still breathable environment such as a decompression chamber? I've read in fact that Argon is also narcotic, in fact even moreso than nitrogen, and in fact all the noble gases are most likely narcotic except for Helium and Neon.
pubmed.ncbi.nlm.nih.gov
