MephedroneCandy
Bluelighter
- Joined
- Mar 18, 2022
- Messages
- 88
I found IC50 for taar1, for MAO, for everything except reuptake transporters!!! Even in bindingdb.
Edit: Solution to the exercise
Racemic Methamphetamine: DAT Ki=0.46 μM, NAT Ki=0.11 μM
S isomer 17 times more potent at DAT and twice at NAT than R isomer.
2/0.46=(1/17x)+1/x
S isomer DAT ki = 0,24 μM
2/0.11=(1/2x)+1/x
S isomer NAT ki = 0,08 μM
So it is true. R methamphetamine really has negligible affinity for DAT like we knew.
And the S isomer still is disbalanced for NAT.
Destromethamphetamine has a DAT/NAT affinity ratio identical to amphetamine contrary to popular belief (1:3)!!!!! Even though it probably release more dopamine thanks to sigma1 affinity, which in methamphetamine case, helps the reversal of DAT,
Edit: Solution to the exercise
Racemic Methamphetamine: DAT Ki=0.46 μM, NAT Ki=0.11 μM
S isomer 17 times more potent at DAT and twice at NAT than R isomer.
2/0.46=(1/17x)+1/x
S isomer DAT ki = 0,24 μM
2/0.11=(1/2x)+1/x
S isomer NAT ki = 0,08 μM
So it is true. R methamphetamine really has negligible affinity for DAT like we knew.
And the S isomer still is disbalanced for NAT.
Destromethamphetamine has a DAT/NAT affinity ratio identical to amphetamine contrary to popular belief (1:3)!!!!! Even though it probably release more dopamine thanks to sigma1 affinity, which in methamphetamine case, helps the reversal of DAT,
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