Pharmacology Where the fuck can I find the ic50 for DAT and NAT for dextro (S)-meth?

[MephedroneCandy]

Library Genesis

libgen.li

Hotlink to long paper.

By use of in vitro uptake and release
assays, d-methamphetamine is 17 times more potent in releasing dopamine than l-methamphetamine and significantly more potent in blocking dopamine uptake.

In vitro, d-methamphetamine’s potency for
norepinephrine release is twice that of l-methamphetamine, which may account for the greater cardiovascular effects that we observed in response to d-methamphetamine.

S Methamphetamine is a shitty molecule, also its NAT affinity is more than the R isomer. It remains extremely disbalanced.

 

[MephedroneCandy]

Racemic Methamphetamine: DAT Ki=0.46 μM, NAT Ki=0.11 μM
S isomer 17 times more potent at DAT and twice at NAT than R isomer.

2/0.46=(1/17x)+1/x

S isomer DAT ki = 0,24 μM

2/0.11=(1/2x)+1/x

S isomer NAT ki = 0,08 μM

So it is true. R methamphetamine really has negligible affinity for DAT like we knew.

And the S isomer still is disbalanced for NAT.

Destromethamphetamine has a DA/NA release ratio identical to amphetamine contrary to popular belief (1:3)!!!!!