I've tried most sleep aids without success. Benzos cause a paradoxical reaction. Seroquel gives me akathisia. Clonidine works at about 0.2mg but I feel very agitated and worked up the next day.
I've been using Doxylamine succinate -- up to 50mg -- over the past couple of weeks, occasionally switching in cyproheptadine as well. I notice tolerance builds quickly for some reason (maybe because I've been using them on and off for the past year). The past few days, 50mg of Doxylamine has done nothing .. I tried substituting it for 20mg of amitriptyline 4 hours before bed, but no response either.
Because I'm so desperate to sleep and it's such a huge ordeal every single night (long story), I asked my GP for Mirtazapine. My impression was it was *more* sedating at lower doses, so I took 7.5mg before bed. An hour later, I felt nothing except a little mental/physical sedation (cross-tolerance with anti-histamines?); anyway, for the hell of it, I thought I'd take the other 7.5mg and fell asleep within 5 minutes.
What happened? Was it more 5-HT antagonism at 15mg? Mirtazapine made my anxiety hell-ish when I tried it at 30mg a few years, and I feel a little on edge today (though kind of stoned as well), so I don't know how sustainable this can be.
But I'm wondering why 15mg knocked me out when 7.5mg didn't, and if I should maybe try an even lower dose, or possibly taking it earlier before bed?
I've been using Doxylamine succinate -- up to 50mg -- over the past couple of weeks, occasionally switching in cyproheptadine as well. I notice tolerance builds quickly for some reason (maybe because I've been using them on and off for the past year). The past few days, 50mg of Doxylamine has done nothing .. I tried substituting it for 20mg of amitriptyline 4 hours before bed, but no response either.
Because I'm so desperate to sleep and it's such a huge ordeal every single night (long story), I asked my GP for Mirtazapine. My impression was it was *more* sedating at lower doses, so I took 7.5mg before bed. An hour later, I felt nothing except a little mental/physical sedation (cross-tolerance with anti-histamines?); anyway, for the hell of it, I thought I'd take the other 7.5mg and fell asleep within 5 minutes.
What happened? Was it more 5-HT antagonism at 15mg? Mirtazapine made my anxiety hell-ish when I tried it at 30mg a few years, and I feel a little on edge today (though kind of stoned as well), so I don't know how sustainable this can be.
But I'm wondering why 15mg knocked me out when 7.5mg didn't, and if I should maybe try an even lower dose, or possibly taking it earlier before bed?