Two studies, addition of DET and Tryptamine to mushroom substrate

[Thanatos]

Would it be possible to obtain 4-PO-MET using the same tek as yaesutom described in the first page?

 

[yaesutom]

^^ Yes if you add MET you'll probably get mostly 4-HO-MET out and a little 4-PO-MET.

I wonder if 4,5-dihydroxy-DMT is able to get into the brain? Yopo seeds are a really cheap source of bufotenin (5-HO-DMT). I also wonder if 5-HO-DMT is more able to get taken up by the enzymes because its a little smaller than 5-MeO-DMT.

 

[serotonin2A]

You probably don't want to find out if 4,5-dihydroxy-DMT can get in the brain. Dihydroxylated tryptamines tend to be neurotoxic to monoamine neurons. They are transported into cells and autoxidized to cytotoxic diquinone derivatives. The best known examples are 5,6-dihydroxytryptamine and 5,7-dihydroxytryptamine, but 4,5-dihydroxytryptamine is also apparently neurotoxic.

DMT derivatives can be tranported into serotonergic neurons, so dihydroxylated derivatives of DMT are potentially neurotoxic.