dopamimetic
Bluelighter
- Joined
- Mar 21, 2013
- Messages
- 2,071
Was just wondering about how predictable and avoidable the toxicity of compounds really is, and how over-focused the pharma industry possibly is on avoiding psychoactive, addictive effects in their new products at the cost of accepting limiting physical side effects. So many of approved medicaments have strong physical side effects and a pretty narrow dose window. Just the first example that comes to my mind as I am on it, tramadol and venlafaxine are roughly equipotent but take too much of vena and you get migraine like headaches. Do that with tramadol and you're high (with a risk for seizure though but I am more referring to things which the majority gets, probably you can never avoid individual bad reactions but many medicines have effects that many users will get). Granted, there's a notorious lack of data about drugs especially RCs, and maybe medicine tends to be used for longer periods of time, yet do I somehow have the impression that a good part of RCs have a striking safety profile given the fact that most of them never went through any real clinical trials if we exclude poorly researched shit like the chloromethcathinones, some noids etc.. e.g. 2F-/DCK are afaik very probably safer than K, the fluoroamphetamines feel more safe (disputed I know).. the diarylethylamines should be safer than arylcyclohexylamines.. even bromadol was nice, just too potent. 4,4'-dmar needs to be used with caution but might be physically safe when done so, maybe the only balanced SSRA/MAOI that actually works and you don't need to diet with it..(I've accidentally combined with venlafaxine w/o ill reactions!)
People are using the shit out of them yet from what I've seen they are similar to the classic illegal drugs and some medicines are worse.
Just some fancy thinking but looking at other big industries like tech giants it wouldn't really surprise me if some genious individuals could come up with equally good or better things than big corps and given how many promising compounds fail in clinical tests or get withdrawn cause of probands liking them (yiek), well..
Maybe a factor is that RC users tend to be more wary about negative effects than people taking meds with the added indirection of them experiencing the side effects but the doctor deciding about continuation and positive effects not being felt immediately for many meds with the belief that you need to go through negative ones like with the antidepressants but still, guess people would have predicted the RC phenomenon to have worse consequences. I know there are many deaths but these would have happened with anything and are directly related to the War on Drugs (reckless combinations etc).
People are using the shit out of them yet from what I've seen they are similar to the classic illegal drugs and some medicines are worse.
Just some fancy thinking but looking at other big industries like tech giants it wouldn't really surprise me if some genious individuals could come up with equally good or better things than big corps and given how many promising compounds fail in clinical tests or get withdrawn cause of probands liking them (yiek), well..
Maybe a factor is that RC users tend to be more wary about negative effects than people taking meds with the added indirection of them experiencing the side effects but the doctor deciding about continuation and positive effects not being felt immediately for many meds with the belief that you need to go through negative ones like with the antidepressants but still, guess people would have predicted the RC phenomenon to have worse consequences. I know there are many deaths but these would have happened with anything and are directly related to the War on Drugs (reckless combinations etc).
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