I've just had my mind totally blown for the first time by DMT, and I'm still in awe of what just hapenned. I would call it fucking unbelievable, real magic and awesome beyond comprehension, if it didn't sound so trite.
After hitting a nice dose, I felt compelled to get up and walk through my apartment. The world around me was morphing into different forms, for real, as real as I see it awake. Not like other psychedelics where I can clearly separate the illusions from reality.
And then, I became possessed. Someone was operating my body like a puppet, and I was just a passenger. I could sense the waves of energy coursing invisible towards my body, my hand rising to meet them, and then I felt them flowing through my body, swirling it into a dance. The amount of beauty, the vividness and complexity of what I saw when I closed my eyes was unbelievable. The world around me was shifting between different universes, each with its own texture of matter, color palette, level of complexity and fluidity. The dominant thought I had was wow, there actually is a lot more to life than I had thought...
I was reading a thread about whether there are persisting benefits from smoking DMT. I don't know about depression, but for derealization, existential doubt and ennui it's just what the doctor ordered. If I had thought I had seen it all, and imagined all that the universe has to offer, this has blown my mind far, far away again.