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Misc The (LOPERAMIDE) diaries...

By the by, a not so novel approach to cross the bbb with loperamide in lieu of concurrent administration of p-glycoprotein inhibitors is this:
Place the tablets under the tongue.
Sublingual dosing dissolves the tablets rapidly, providing rapid onset and a convenient way to circumvent the normal pharmacokinetic movement and absorption within the body.
 
Not when compared to the Australian food spread Vegemite. One shudders just thinking of that abomination.
And I assume anything beats gut-rot and volcanic rectal gas explosions. ;-p
 
toothpastedog said:
That sounds like it would taste beyond nasty
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well make one drug that already someone wouldn't call nasty if the drug test the job done which I want to know ^ then it's meaningless.

On a side note wouldn't a better way be just to dissolve the lopermine in water? I have tried this though with the UK tabs and sadly the powder just sits at the top of the water making it pretty much unsolvable even after crushing true say to I drank one just to see what I would be like and it tasted beyond nasty. Can't remember if it worked though also tried adding some to a filterd codeine solution again can't comment if it worked because I couldn't tell.

Little druggy tip: Sainsbury pure mango juice (from concentrate) seems to poteniate codeine I dunno weather it just helps clear out my stomach lining and help the tablets reach my stomach faster or something else can't hurt to try anyway it tastes nice and it's good for you ��
 
Loperamide pills (not the capsules, but the pressed pills) make me gag taking them normally, so I couldn't imagine how disgusted I'd be if I tried consuming them in solution.

PPT and cactus "tea" are probably the nastiest drugs I've experienced with, but they're not too disgusting to consume given the effects. Loperamide, I couldn't justify the disgusting bitterness given how the stuff works.

To each one's own though. Not judging anyone for how they take loperamide, although I would caution going easy on it.
 
IIRC Loperamide is barely water soluble so dissolving it in water doesn't help except to guzzle the sludge down maybe. Oddly enough the club store generic lope pills dissolve in seconds in your mouth after you take a sip of water. Though only one box of 400 can be purchased at a time from the in store pharmacy now.
 
In the UK we don't have lopermine tablets on my capsules and instant releases which are more expensive trouble is the 'instant reviewer's don't always dissolve on my tongue like they're supposed to so they're a waste my pharmacy though does a generic cheaper version of the capsules I can buy a pack of 30 for just a bit more than one would pay for cocodomal all this pharmaceutical talk is making me want some paramol and prometazine unfortunately I've only had enough to get essential codeine from cocodomal and nothing else it's funny because when the first couple times I did dhc and lopermine I didn't feel them at all( I felt codeine the first time I tried it) but after trying them and a bit of progress and error I can get a nice high off 4 mg lopermine under the right circumstances and dhc has an interesting high to it now to.
 
You get a "nice high" from 4 mg of loperamide? That must be a typo or Your imagination my friend
 
Look I'm sorry but I'm not gonna lie or get in a stupid argument but honestly I took two capsules not expecting anything really.then boom it hit me and I hadn't had any other opiate other day I hardly take.the shit the 'high' still isn't as good as codeine or even dhc so I use them for last really. It is a great drug though and I've usually always got lop e lying around because I never really use it but it's good to know I have some if I want.
 
Patrickforsterter said:
Look I'm sorry but I'm not gonna lie or get in a stupid argument but honestly I took two capsules not expecting anything really.then boom it hit me and I hadn't had any other opiate other day I hardly take.the shit the 'high' still isn't as good as codeine or even dhc so I use them for last really. It is a great drug though and I've usually always got lop e lying around because I never really use it but it's good to know I have some if I want.
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Hey Patrick, I spend plenty of time telling people not to get into trouble with long Q-T syndrome/ Torsades de Pointes from mega dosing. I wasn't mocking you at all, just saying more power to you and if 4 works then try to keep it under 8 in case you have a sensitivity. Lope addiction is a morbid habit, the fact you don't need megadoses is a win-win for you. If someone gives you a hard time it's most likely from jealousy. PM me if I can be of any assistance. JA
 
Jekyl Anhydride said:
Hey Patrick, I spend plenty of time telling people not to get into trouble with long Q-T syndrome/ Torsades de Pointes from mega dosing. I wasn't mocking you at all, just saying more power to you and if 4 works then try to keep it under 8 in case you have a sensitivity. Lope addiction is a morbid habit, the fact you don't need megadoses is a win-win for you. If someone gives you a hard time it's most likely from jealousy. PM me if I can be of any assistance. JA
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I was replying to the slightly ignorant post above yours I appreciate the hr though.
 
I defo feel moremore energetic number and they probably haven't fully kicked in yet honestly every junkjunky should have some poor man's methadone lying around it's great:D I feel happy
 
I'm glad Lope's working for you PF but as you'll find out it's not all roses & rainbows. You will find stomach cramps, discomfort in the transverse colon among other well elucidated points brought up farther back in the thread end up being more commonplace with regular lope use.
 
Jekyl Anhydride said:
I'm glad Lope's working for you PF but as you'll find out it's not all roses & rainbows. You will find stomach cramps, discomfort in the transverse colon among other well elucidated points brought up farther back in the thread end up being more commonplace with regular lope use.
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That just proves medical and biological sciences are still sexy ;)
 
Scrofula said:
Sweet Patrick, alas, the good moralists of the United States have seen fit to remove codeine containing products from our shelves across the land. Instead, the good corporate masters at Johnson&Johnson have decided our livers are all better off if we add acetaminophen (paracetemol to socialists) to every last ounce of consumer goods possible.

Now it seems our citizens, cleverest bears around, have resorted to grossly unsafe overdosing on diarrhea meds instead. Well, the important thing is, Jesus would prefer it this way, especially when acute hepatotoxicity (nee Archangel Michael) brings the good ones to him sooner.
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So true!
Excellent comment!
 
Hello everyone...I have quite the story but don't have the time to write it all out right now. All I want to say is get off love NOW before it kills you or ruins your entire life. I was on this drug for four years after my back surgery. Before surgery, I had been on some type of opiate for at least 15: years. Doctors just pushed the pills, and I willingly took them because who wouldn't? Anyway, after surgery, I was still taking pills, and I was given an ultimatum to either stop taking opiates or be forced into rehab and be alone. I researched my options and found lope as the miracle cure, or so I thought. I took 20 of those green little nasty pulls and was fine all day. I couldn't believe it! I could literally go to Sam's and buy 6 or more boxes and be set. I worked my tolerance up to taking 200mg a day. I hid empty bottles every where and hid my stash in my trunk under my spare tire. My partner questioned my sudden need to take diarrhea meds ask the time, but she NEVER knew just how many I was taking. I told her it was to control the ibs I had developed from years of opiate abuse, which is kinda true. Well, fast forward four years, and my life seems ok, but I'm totally broke, in debt, need to file bankruptcy, and have ruined almost every relationship with friends and family. Despite all that I've caused, I've kept my job, managed to keep a roof over my family's heads and food in their tummies. I was doing enough to just make it, but my life was in a complete fog. I am surprised I didn't get fired, but I'm great at my job, but my mouth was like no other when in a lope state of mind. I took it every single day without fail for four freaking years. My partner and I had a kid while I was on lope. Luckily, I'm not the child's biological parent bc God only knows what I would've produced. Despite my addiction, I was and am a good parent, but could've been way way better.
I have my child to thank because without him, I would've kept on taking them. Things just kept getting worse; it was like Something was punishing me for being so wreak. I started to resent the little green monsters. I hated taking them. It got ridiculous, and I felt like such a loser. I was finally ready to stop and reclaim my life. And that's exactly what I did. It only took that one choice, and it was the best choice I've made in a long time. It took me FIVE months to tartrate down. I jumped from 100 pills a day to 40. I went through mild discomfort but nothing major. Then I slowly got down to 20/day but it took months to get below 20 without getting horrible PAWS. I finally did get below 20 with the help of weed. It's been two weeks, and I feel great. Tonight I'm going to bed without any help. This is the first time I'm my life that I've been completed sober, and I will never ever go backwards. Get off the lope be now. It's just not worth it at all. No matter what you take to help you kick the habit, just remember that replacing something with another substance is s vicious cycle, but cannabis was truly a God send. It's the only drug that made me return to myself and it's not addictive!
 
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