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The Big & Dandy MDAI Thread

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There's something I am wondering for quite some time and figured I would ask the pros: why MDAI doesn't give any sympthom of serotonin depletion being a serotonin releaser? (I'm talking about responsible use and not hammering grams of the stuff at a time). Actually quite the opposite, cause I too experienced a better mood for 2-3 days after bioassay.

I don't remember an answer to this question posted before, if my memory is failing me I apologize.

I feel like I'm missing something on the pharmacodynamics, so maybe someone can enlighten me: let's take the infamous MDMA, it's a serotonin releaser, it does reverse SERT and hence pump the 5-ht out of vescicles, then 5-ht does its job and activate receptors, and then it's destroyed by MAO system. So end of story the 5-ht vescicles are gonna be pretty empty and the brain will be low in 5-ht for some time while the body build up some more. I'm making it very simple and not considering other catecholamine action nor toxicity issues.
Now why this doesn't seem to happen with MDAI? It should still pump out 5-ht, that then should be attacked by MAO and result in 5-ht shortage.
Now the only thing I can think of (in my ingnorance of chemistry and pharmacy) is that somehow with MDAI the 5-ht is not attacked by MAO, so either MDAI is a MAOI, or the 5-ht can slowly go back in the vesicles when SERT action goes back to normal and then it's not wiped out by MAO.

But I'm still :?:?:?
 
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Oddly enough I found the opposite was true for me - never had a crash from even the heaviest MDMA use but felt really low mentally and emotionally for 3-4 days after relatively moderate use of MDAI. Know what those folks who do feel crappy after MDMA mean now but YMMV as ever, I guess.
 
why MDAI doesn't give any sympthom of serotonin depletion being a serotonin releaser? (I'm talking about responsible use and not hammering grams of the stuff at a time). Actually quite the opposite, cause I too experienced a better mood for 2-3 days after bioassay.
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Well, as a caveat, we can't really narrow down the negative after-effects of MDMA to depletion of serotonin alone. However, MDAI has a few advantages over MDMA, which make the former a bit less likely to cause negative after-effects:
1. There is no concurrent release of dopamine, meaning that there will be reduced oxidative stress (at DA and 5ht neurons).
2. Due to its cylcization, MDAI doesn't form the same toxic metabolites that MDMA does.
3. MDAI doesn't inhibit tryptophan hydroxylase as MDMA does.

However, MDAI is not magic; if used in doses a few times the active 150 mg or a few days in a row, you very likely will experience negative after-effects.

ebola
 
Right, you can call me a fan of this stuff now. What I like about it is it gives you the urge/confidence to do stuff you'd do when fucked without you actually feeling/looking fucked. There's a big desire to bond with people and I find it a big aphrodisiac, though not in that dirty meph way. Did my final 250mg bomb from my 1st gram 30 minutes ago and already feel 'nice'. Must try it in a social setting. I doubt i'd get any of the paranoia I got with meph towards the end.

The only thing I'm concerned about is the amount I'm taking to get effect, though someone said it could be a weak batch.
 
anyone tried high dosage of this? upwards of 500mg? pretty sure I got sold some MDAI instead of 6-apb (long story :)... did 70/100/400mg over the course of the day. Feels nice, subtle gently mood ehhanced, mild euphoria, but could be something a bit more special up towards a nice round 1g, per chance?

Thoughts people? :)
 
That's the effects of MDAI - it's subtle. Higher doses (or IV use - not that I could recommend that as such) may produce a somewhat more intense euphoria but it's still fairly subtle. Combo'd with a dopaminergic stimulant (MDPV, methylphenidate etc) it apparently has a "fuller" effect but ultimately it is what it is and what it is is mild, mellow and subtle. Taking a gram at a time is probably a very Bad Idea indeed - may be subtle but can have one hell of a sting in the tail the next day and higher doses alone don't make the experience any more rewarding, I find. Check this thread for ideas and reports on combos - goes great with psyches :)
 
cheers shambles, i'll save the rest... maybe do it in combo when these mysterious pellets when come to fruition??... although prolly wont need to by sound of it, be in too much of a silly lovey mess to even contemplate bothering :)
 
MeDieViL said:
Yeah, apperantly some batches have a purity of 40%:|
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Can you tell by looking? Mine was a tan powder. Didn't go clumpy or wet like some pics I've seen.

How long would people say the high from a dose should last? I thought this was weakening after an hour, but it is actually still going and feels better with every glass of wine. =D
 
^ that's probably the wine :) in the same boat at the mo but i'm on the whisky! whats your dosage?
 
JohnnyVodka said:
The nice sounding thing about 6-apb is that no one in their right mind would it attempt it during the week due to the duration and craziness of the high. I'm *hoping* it can be stock-piled.

The problem with meph is there was always that feeling you could have a cheeky line (though a cheeky line would always turn into an all night session :eek:).
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absolutely spot on and the reason i'm glad meph's banned! roll on the pellets:)
 
Osky_P said:
^ that's probably the wine :) in the same boat at the mo but i'm on the whisky! whats your dosage?
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Did a 250mg bomb (possibly a bit more) just after 7pm. Doesn't feel quite as strong as last night. I think I read tolerance build on this is quick?

Not an amazing drug, but quite handy to have around. I'm hoping it's unproblematic enough to not be banned.

It's possible there's a synergy between this and booze, though I remember someone writing they thought booze drowned it out...

Anyone tried it for socialising, like in a club? I know it won't have you dancing, but it def puts you in a good mood. Could be good for chatting up the ladies.
 
JohnnyVodka said:
Can you tell by looking? Mine was a tan powder. Didn't go clumpy or wet like some pics I've seen.

How long would people say the high from a dose should last? I thought this was weakening after an hour, but it is actually still going and feels better with every glass of wine. =D
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Was the sticky, dark brown stuff that was less than 50% - the light tan stuff is pretty good. Duration is similar to MDMA for me - 4-6 hours or so. Bit o' booze certainly slips down a treat :)
 
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JohnnyVodka said:
Did a 250mg bomb (possibly a bit more) just after 7pm. Doesn't feel quite as strong as last night. I think I read tolerance build on this is quick?

Not an amazing drug, but quite handy to have around. I'm hoping it's unproblematic enough to not be banned.

It's possible there's a synergy between this and booze, though I remember someone writing they thought booze drowned it out...

Anyone tried it for socialising, like in a club? I know it won't have you dancing, but it def puts you in a good mood. Could be good for chatting up the ladies.
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agree completely with the booze thing, first time i did this, wasn't blown away until after 2 bottles of wine watching the sun rise in my back garden... i've never seen such beauty in weeds and nettles. can see a similar situation brewing tonight. it certainly hits in waves. subtle waves admittedly but really rather pleasant.
 
You need quite a bit of booze, though - more than just a couple of drinks. But it seems to lie under the booze very nicely. I seem to be just at a nice point now. Reckon it's fairly long lasting.

How much did you dose, Osky_P?

It's the kinda drug that has me going out for a late night walk. I used to get this on meph, until I started getting paranoid on meph and just wanted to do it alone. Last night i was walking around the block, sucking a lolly (don't ask!), not self-conscious at all.
 
JohnnyVodka said:
You need quite a bit of booze, though - more than just a couple of drinks. But it seems to lie under the booze very nicely. I seem to be just at a nice point now. Reckon it's fairly long lasting.

How much did you dose, Osky_P?

It's the kinda drug that has me going out for a late night walk. I used to get this on meph, until I started getting paranoid on meph and just wanted to do it alone. Last night i was walking around the block, sucking a lolly (don't ask!), not self-conscious at all.
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Glad you noticed that JonnyV, re the booze, I've had half a bottle of bushmills with 570mg, done in 70-100-400mg, feel ace.

had a walk out a bit ago to get some cigarettes and had a bumbling encounter with the the lady at coop, where i thought she hadn't give me my fags and i was stood there waiting for them with a daft expression on my face... there were in my pocket. mirth ensued :)
 
If I had any left I'd prob be doing another bomb now!

Gonna finish my wine, then have a whisky, then go for a quick walk.

Anyone else find mdai to be an aphrodisiac?
 
I guess it shouldn't be surprising that in combines well with alcohol and GBL, as both release some dopamine. Any thoughts on the question I posed in my last post regarding aMT? Here it is again for convenience's sake:
I'm thinking two low consecutive doses of MDAI with aMT and amphetamine could make for something like an extended release MDA. Has anyone used it with aMT, and are there any estimates on how much more potent plugging is than oral? Any recommendations on the two dosages of MDAI (plugged) with the other two chems? I plan on taking 17 mg aMT (IM) and 20 mg amphetamine plugged or insufflated with maybe a 10 mg booster later.
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