I think I'd take around 700-800 for 3rd then, and 1000-1100 for 4th, based on what calculators have told me regarding my weight. I might just jump straight to fourth, being a bit of a masochist - I assume if I do this though puking is almost guaranteed?
I definitely wouldn't advise this. The DXM dose-response curve is anything but linear, and even small increases can be shockingly powerful. For me, jumping from ~290 to ~390 milligrams took me from a comfortable, cozy, intellectually stimulating high, to something that shredded my mind so mercilessly that it was a monumental effort to even understand the most basic concepts and ideas.
DXM isn't like psychedelics, which IMO are still relatively kind on your mind and body if you overshoot your aim. DXM can become a veritable psycho-spiritual buzz-saw if you take too much, so please don't "be a bit of a masochist" and jump straight into a fourth plateau dose, if you've never been on at least a high third plateau (and a mid-third-plateau before high-third-plateau, etc.).
half a bottle (150mgs) is as high as i will go... DXM is a dirty droog
half a bottle (150mgs) is as high as i will go... DXM is a dirty droogIt's not dirty, but it can be dark.
I've never personally understood what this 'dirtiness' is that people ascribe to DXM, although I've seen it mentioned often enough. Does anyone care to expand on what that they mean by dirty beyond 'I don't like it'? I personally haven't found DXM itself dirty in any sense, although chugging syrup can be unpleasant.
Is it the need to drink syrup coupled with the potential hot flushes/itchiness/other histamine reactions plus nausea or is it something more?
that really depends on the individual. i know plenty of people including myself that HATE cough syrup. in fact i've had such bad trips on this shit that i won't even take cough syrup when i actually need it to stop coughing!
DXM, as the hydrobromide salt, is absorbed quickly from the GI tract; within 30 minutes, all of it may have entered the bloodstream (2,3). The polistirex compound is intended for continuous absorption, and may take 6 to 8 hours to fully enter the bloodstream.
DXM is metabolized via two pathways, both of which lead to the same thing, 3-hydroxymorphinan (3HM). The first pathway goes from DXM to DXO (dextrorphan) and then to 3HM; the second goes from DXO to 3-methoxymorphinan (3MM) and then to 3HM. By far most of the DXM (up to 90% ) gets metabolized via DXO in normal individuals.
DXM is converted to DXO by a liver enzyme called cytochrome P450-2D6 (debrisoquine 4-hydroxylase). About 7% of Caucasians and 0.5% of Asians have a highly inefficient (70 times slower) version of this enzyme, and cannot metabolize DXM to DXO effectively (10). About 0.5 to 2% of the population have multiple copies of the P450 gene, leading to extremely fast metabolism of DXM into DXO (155). After being converted to DXO, the enzymes P450-3A4 and P450-3A5 convert DXO to 3-hydroxymorphinan (77).
The other pathway goes to 3-methoxymorphinan first (via P450-3A4 and P450-3A5), and then to 3-hydroxymorphinan. Most people do not metabolize much DXM this way, although people who lack the normal P450-2D6 will convert a substantial amount to 3MM. As 3MM is probably not psychoactive, this means that the 5-10% who lack the normal 2D6 enzyme will experience less effect from DXM (or more specifically, won't experience the effects of DXO).
P450-2D6 functions by removing the methoxy group and replacing it with a hydroxyl (OH) (or more accurately, pruning the methyl off the oxygen); this step is known as O-demethylation. P450-3A4 and 3A5 replace the methyl group with a hydrogen (H); this is the N-demethylation step. Refer to the diagram of the DXM molecule in Section 4.2 for the location of the methyl and methoxy groups.