I have found that in almost all circumstances, especially in my own experience with a few of the 2c series, that staggered dosing is an excellent way to avoid come-up nausea! However, I did not staggered doses of DOC when I had it in because I thought it felt pretty easy on the system at the 1.5mg dose I preferred. However, once the material began to run out I upped my dose to 2mg & suffered a brief but unavoidable return of an instant coffee & a glass of OJ, which is all I had in my stomach. I suspect that staggering the doses of DOC might simply extend the experience, & it's honestly long enough, this stuff!