Somehow I have invented the term
MXEoids for these compounds (MXE aka 3-MeO-2'-OxO-PCE & 3-MeO-PCE for now, v.s. O-PCE etc - I'm unsure yet whether this is individually, genetically and/or metabolism, tolerance etc. dependent).
For me, if MXE is the
, then 3-MeO-PCE is the vodka (in terms of distilled, pure but very strong). This isn't the best comparisation, because PCE has a much slower onset and much longer duration, but I can't find a better one atm. They hit the exactly same receptors, in differing strength and so, but share something
no other substance I know of, and the number isn't exactly small, is able to do.
This nice comfortable cozy warmth, together with absolutely calm smooth stimulation, anxiolysis, 
-opening effects ... granted, I have never done MDMA yet and probably I've been wrong with associating this warmth to opioids and it's more of serotonin than opioid (the term doesn't come from opi-oid but from "gabapentinoids" where they started this, though
) ...
Can anyone clarify this for me
Is it pure 5-HT (the compound for sure inhibits, if not reverse agonizes, SERT) or does mu agonism play a role too? When NMDA is antagonized, opioid activity will become "forgiven" to some degree in that one won't get tolerant or withdrawal - this is currently in the papers for pain therapy etc..
Don't take 3-MeO-PCE while you're on antidepressants, tilidine, tramadol, or together with DXM for now.
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At first, I have never ever reached a true "hole", where I would have lost consciousness, control or touch with my body or a complete ego dissolution on
any dissociative including K (up to 750mg or so). Maybe this is genetical, I suspect to have too much glutamatergic activity (dissociatives work by blocking glutamatergic NMDA receptors) what also leads to psychiatric / neurologic problems, so I can only speculate.
But who had problems to hole on other substances, or worse, freaked out - please don't attempt on this . - it is not immobilizing and brings a huge energy with it. Up to now all reports I've read including my own experiences were positive, and I think this compound has a very uplifting nature as the inventor also described it -
but remember, what comes after uplifting energy - mania. You don't want to cross that threshold by dosing too high. It will be a trip to the ER, and it will bring you and others hard trouble.
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I get a borderline hole state though when I lay down in a dark room, the darker the better, so that no more sensory input comes from the eyes. Then I would start to float away from the outside world, like drifting on a river (or a rollercoaster, depending on the drug and dosage) through imaginary worlds constrcted by my brain usually from the things seen on the last day or so, but mostly it's a natural environment. Usually only slightly visible and black & white, but twice or so I also got colors ... this is a very deeply relaxing experience that I somehow think of as chemically catalyzed meditation and I feel afterwards usually refreshed as if I had slept some hours. I could get up and do things however at any point, it's like having two bodies, one real and one in the dissoverse. Have yet to learn to control the disso one - once with DXM I could control the world around me, but it was very rudimentary, like I had to learn body control first, and then walking again ... (what I think is really quite similar in how it works in the brain!). And a freak-out in this state would be
bad because there is
no immobilization at all.
This has become longer than intended, but I leave it here because with 3-MeO-PCE I had a very intense experience of this state. With K I get it too but it's usually cold and abstract, this one here let me flow through endless cities in warm summer nights to relaxing music (listening to music, with good headphones, is essential for me to achieve this.. don't know for others of course).
Also the effects and afterglow last well up to 48h especially with one redose. There might be a
slight serotonergic crash, sadness occurring at the tail end, be prepared for this if you're sensitive to emotions and 5-HT. Most people don't seem to be to the level I am, but it's better to be safe than sorry. I know of at least one more person personally who crashed hard on MXE. Because it all feels so naturely and pure, and the crash consists of pure heart pain, sadness and regret, the thought of taking a drug couldn't be further away. Once I've even flushed a good stash of MXE due to this before I realized what it was.
So be prepared. Redosing won't help because of the slooow onset. A tiny bit of ketamine does the trick, or a benzo, whatever you prefer.
You can ride it out of course, it's purely mental, but can get intense. Is crashing on MDMA like this??
Take care! After so long time, we have a winner
. But it needs to be treaten very cautiously. Think of it as a huge motorcycle of which you don't know yet how strong it accelerates, or so (at least until you know the compound).
Bring us more MeO substituted PCMs and PCEs!
