Hey all, I have some questions for you related to the come-up of 25i, as well as what you believe to be its overall safety. Additionally, I would like to share some of my experiences from the most amazing night (and most incredible trip) of my life that I spent on ~500ug of 25i.
I have tripped on 25i multiple times, and every time I have noticed that the come up period is generally very upsetting for me. I get strange and uncomfortable feelings in my stomach accompanied by a worrisome shakiness. In fact, I have noted that it takes about 2 hours for me (after putting the tab in) to start to feel like the uncomfortable feelings are finally residing and I begin to truly enjoy the trip. The strongest dose I have taken, and generally take is ~500ug (half of a 1mg tab,) which seems to be on the low side of the average dose, but causes an intense trip for both me and my girlfriend.
My most recent trip was the strongest, and due to this I had the most difficult time during the come up, and the most incredible time afterwards. It was ~500ug like I said, spent with my girlfriend who also had half a tab. Time of dosage was quite late in the night (which probably added to my anxiety.) My girlfriend and I had driven to my home from college that day to begin spring break, and were a little tired at the start of the trip, but nonetheless prepared and excited, for we had been planning the trip all week. I had taken a multivitamin earlier that day, maybe 6 hours prior to dosing, had eaten a full dinner around 4 hours prior to dosing, was hydrated, etc. It had been around 2 and a half weeks since my previous trip on 25i.
During the come up I anticipated the negative effects and tried doing many things to relax and curb my anxiety. I tried moving around my room, stretching, dancing to music. Lying down, trying to monitor my breathing. Listening to exciting music, listening to calm music. Watched my girlfriend play a video game. Took a bath. Nothing seemed "right" and the first two hours of the trip seemed to stretch on and on. I found it difficult to discuss my anxieties with my girlfriend because she seemed to be doing great and I didn't want to upset her. She agreed the come-up was uncomfortable but didn't seem preoccupied by it. However, the uncomfortable body feelings were all I could think about. At around an hour and a half after dosing I noticed that my legs were really shaky. Simply walking up and down stairs seemed difficult. My girlfriend told me my muscles were tired from driving a long distance and that she was also shaky, told me not to worry, but I continued to worry.
Reaching the 2 hour mark didn't seem to help, and I told my girlfriend I thought we should be done with 25i after this trip and that if anything happened to me she needed to make sure I got medical attention. She told me she would, but also assured me that I shouldn't be worried. She reminded me that a half tab of 25i isn't a large dosage, that we were being safe and in a safe place, and that it's normal to feel uncomfortable at times while tripping. We agreed that I was perhaps simply tripping too hard and having a bad trip. At that point in time I took half a pill of etizolam. We agreed that a change of setting might help a great deal, and we went outside. Things turned around shortly after that, which I believe was likely due to the etizolam and the change of setting.
What followed was the most amazing experience I have ever had. My girlfriend and I both opened up in ways we never thought possible, we told stories from our childhood and connected deeply through the brilliance of conversation. Although we had been dating for over a year, we both agreed that we felt as if we had learned how to love each other for the first time again. We had some striking realizations about our lives and things we would like to change and improve on upon returning to finish the semester after spring break. We felt as if we could take on the world.
Most of the trip was spent talking together, and we didn't discuss my come-up issues very much. We decided we wouldn't trash the 25i, because the experience we were having was far too amazing to give up, but we also agreed we'd have to be careful and figure out some ways to address the issues I was having before trying again.
So my main question is this one: do I truly have anything to fear with 25i? Could a dosage that small (~500ug) be dangerous?
Do any of you have strong negative side-effects during the come-up? If so, what helps? Did I do anything wrong?
I'll answer questions if needed, and I'll likely post a trip-report with specifics at some point if there is any interest. Wish I could do so now, but it's getting late and I don't think I would be able to focus enough to write a serious report.
TL;DR: Nasty come-up on 25i, seeking advice.
Edit: I think it is also worth mentioning that the 500ug was more than enough to cause visuals: more than any visuals I have ever experienced on 25i or any other chemical. I didn't mention them in the above description because the conversational aspect of the trip was far more rewarding and a much larger part of our experience that night. Just for your reference, I did have visuals.