Opioids Tapentadol Megathread

[GetMeOutOfThisCRAP]

I would say it was "nice" but not great. However I would agree that it is one I might have to learn to use..for instance next time I'd probably jump in with 200mg straight away as the whole chasing thing was annoying. I think my codeine tolerance/my brain wanting codeine may have also ruined it slightly. Can imagine it'll be more fun next time now I know what to expect and what my dose/response feels like. New opiate dosing and redosing is always a fiddly game especially when you have cross tolerance with something else. Unlikely to get it right straight away

That's good. Its good people don't find it that addicting then. For me its the exact same as oxycodone, just a more rugged high without the feeling of purity. I could easily ruin my entire life with a constant supply of taps. Even something like tramadol is incredibly addicting and hard to control the use for. I guess some people just maintain control a little better for anything besides heroin. I find taps to be incredibly addicting once you get used to it. It could have to do with my tolerance for opioids never getting that high. Despite the long on-and-off use over the years, my tolerance never really needed that much to catch a high. A few weeks ago I had an ample supply of tapentadol. Like... A LOT. I was kind of relieved when I ran out because it was just too easy to be high all day and everyday

I'm sure people would prefer ruining their life on oxycodone or heroin, but tapentadol is known for being capable of abuse and that is referenced all over the internet. Just wanted to relay, tapentadol and many of the drugs people order online HAVE NOT been given the standard testing/FDA approval seals. You legitimately have no idea what putting tapentadol into your body could be doing. We flat out do not know if it is an unsafe opioid or not.

 

[Azed]

That's good. Its good people don't find it that addicting then. For me its the exact same as oxycodone, just a more rugged high without the feeling of purity. I could easily ruin my entire life with a constant supply of taps. Even something like tramadol is incredibly addicting and hard to control the use for. I guess some people just maintain control a little better for anything besides heroin. I find taps to be incredibly addicting once you get used to it. It could have to do with my tolerance for opioids never getting that high. Despite the long on-and-off use over the years, my tolerance never really needed that much to catch a high. A few weeks ago I had an ample supply of tapentadol. Like... A LOT. I was kind of relieved when I ran out because it was just too easy to be high all day and everyday

I'm sure people would prefer ruining their life on oxycodone or heroin, but tapentadol is known for being capable of abuse and that is referenced all over the internet. Just wanted to relay, tapentadol and many of the drugs people order online HAVE NOT been given the standard testing/FDA approval seals. You legitimately have no idea what putting tapentadol into your body could be doing. We flat out do not know if it is an unsafe opioid or not.

I agree, it was definintely too easy to get hooked on the Tapentadol. Many people in the U.S. believe that it should be less controlled (not a C2). But I think that it should remain in its current schedule until more research and testing is done.

 

[carbonhalo]

Oh crap.
It looks like my insensitivity to hallucinogens and a variety of other pharmaceuticals has struck here too.(got a thread on that)
I had slight effect from tramadol, nearly no effects from both pregabalin and Gabapentin in any dose I could titrate out of a single box and Tapentadol was the most disappointing of all.

 

[GetMeOutOfThisCRAP]

Yeah, in the US it's schedule 2 and I think I only saw it once in three years. It was brand name only it was the Nuctyna ER formulation. I've never seen the IR in the pharmacy, but that's all I got. Works great for the pain that I have in my back.

Ohhhh oh my god. So thats what "Nuctyna" was. Good to know, lol.

For people from the chronic pain perspective tapentadol's a pretty good painkiller. I doubt anyone here would find it "just as effective as oxycodone" but it does work enough to make a difference.

From the drug addict "I want fun" perspective, I'd rate it probably a 6.5/10 lol. Opioids like percocet being an 8/10 for comparison. Its still the same dead end as any, though. You'll reach a point where whatever doses you're on, it just doesn't do the same things it used to in the beginning. Someone could ruin their life off tapentadol addiction for sure.. but just not as obvious or rapidly as oxycodone addiction could.

 

[Azed]

WARNING: I'm sure its been said before but haven't checked the thread, if you exceed over 600 mgs in a day there is toxic effects on the liver/heart. That is the difference between this an oxycodone. There is a toxicity to the liver post 6 tablets in a day (assuming the tablets are 100 mgs each). Its very efficient, but just as addicting as any commonly abused opioid if not more.

When I last had access to Clinical Pharmacology and Micromedex I believe the max pharmaceutical dose war around 500 mg / a day. Additionally, according to the monograph for Tapentadol ER in the US it states this, "oral daily doses greater than 500 mg of NUCYNTA® Extended- Release have not been studied and, therefore, are not recommended." The monograph also states, "The CNS- and gastrointestinal symptoms are concordant with the pharmacodynamic effects of MOR agonists. In rats, adaptive
NUCYNTA® Extended-Release (tapentadol extended-release tablets) Product Monograph Page 40 of 50 changes of the liver were seen. These changes are considered to be related to the xenobiotic overload
of hepatocytes due to substantial phase II metabolism and are not regarded as a sign of overt hepatotoxicity. Additionally; there was a lack of relevant tumour formation in the liver in both rodent species (rats and mice) in the 2-year carcinogenicity studies".

In regards to your comment on cardio-toxic effects the monograph states this, "In dogs, transient prolongation of the QTc-time was observed in repeat-dose studies. The effectsincreased with dose and were significant only at the beginning of the studies. No otherelectrocardiographic findings were observed. Some late toxicity, including convulsions and deaths inrats and dogs occurred in the high dose groups with a delay of several hours following intravenous ororal administration. The cause of these deaths remained unclear, but is regarded as a result ofexaggerated pharmacodynamic effects of the compound".


Therefore, even if this monograph information is to be trusted then we must still main vigorous of our internal health.


Best Wishes and remain safe!
Azed

 

[GetMeOutOfThisCRAP]

When I last had access to Clinical Pharmacology and Micromedex I believe the max pharmaceutical dose war around 500 mg / a day. Additionally, according to the monograph for Tapentadol ER in the US it states this, "oral daily doses greater than 500 mg of NUCYNTA® Extended- Release have not been studied and, therefore, are not recommended." The monograph also states, "The CNS- and gastrointestinal symptoms are concordant with the pharmacodynamic effects of MOR agonists. In rats, adaptive
NUCYNTA® Extended-Release (tapentadol extended-release tablets) Product Monograph Page 40 of 50 changes of the liver were seen. These changes are considered to be related to the xenobiotic overload
of hepatocytes due to substantial phase II metabolism and are not regarded as a sign of overt hepatotoxicity. Additionally; there was a lack of relevant tumour formation in the liver in both rodent species (rats and mice) in the 2-year carcinogenicity studies".

In regards to your comment on cardio-toxic effects the monograph states this, "In dogs, transient prolongation of the QTc-time was observed in repeat-dose studies. The effectsincreased with dose and were significant only at the beginning of the studies. No otherelectrocardiographic findings were observed. Some late toxicity, including convulsions and deaths inrats and dogs occurred in the high dose groups with a delay of several hours following intravenous ororal administration. The cause of these deaths remained unclear, but is regarded as a result ofexaggerated pharmacodynamic effects of the compound".


Therefore, even if this monograph information is to be trusted then we must still main vigorous of our internal health.


Best Wishes and remain safe!
Azed

Okay, it is great that you located that information. Its been some time now, and I strongly dislike tapentadol--actually. It makes you really out of it in terms of brain fog and losing your train of thought typically throughout the day. It happens multiple times within a half hour before and after the effects start and fully decay. I would hate to be a chronic pain patient and perpetually prescribed tapentadol. It works decently for pain relief, but the mental aspect of the effects are more debilitating than most opioids I have ever encountered. I don't mean they make you dysfunctional, but the noticeable lack of feeling clarity with your own train of thoughts makes me realize the superiority of other opioids commonly prescribed. For instance, on percocet you can definitely be so out of it and drooling in front of people--but on reasonable doses you don't become as tired of being so out of it all the time within your own mind. For pain relief, its probably the same thing as any opioid. Your tolerance catches up to you, and then you can't surpass the unknown dose range for prolonged periods and actually know what is happening to your body. For anybody reading, the brain fog is very indescribable in words on tapentadol (but you'll know exactly what I am talking about should you try it). I don't understand what causes the symptom of losing your train of thought. Horrible in a minor way, but enough to complain about. Same with the dry skin and very dry mouth symptoms I experienced. Look much healthier off the drugs lol. Opioids never dry out my mouth or skin like tapentadol did. Unique weirdness so pick your poison if you do have legitimate pain.

 

[crackhead226]

This drug is pretty weird. I execpted it to be like tramadol but it was more like oxy and a benzo mixed together. Also throw in some LSD in the mix. The high was comfy but very short lived, maybe 1-2 hours and it goes and comes back in waves. I crushed 200mg, took 200mg again a few times but the first dose was the best. I won't take this drug again for a while but I imagine it could be comfy if you are sick or have some physical pain. Memory problems for sure, it makes time go faster.

 

[lolis my thesis]

Man I take methadone for pain
Tapentadol worked a charm but at about 200 mg
I would descend into a dreamlike state; I would fall unconsciouos mid sentence
completely lose my train of thought mid gesture; more like a brain fart than a total nod; then I would come to and try to recall what the fuck I was saying, without being too obviously impaired. pretty sure I was indeed obviously impaired!
I gave up my script as I would just blow thru it in a week.
If I took enough also I felt like I was floating with no sensation of having legs; but feeling wobbly like a baby giraffe in those cases.
It really made me too fucked up even compared to hydrocodone but given that ones hard to feel as strongly being on methadone too

 

[silver_lining]

I have been taking Tapentadol off & on for about 2 years now. Not my favorite opiate, but a damn good one when it comes to pain. Recreational use is a bit strange, I find it best used with Soma & Valium as by itself I find it quite speedy, which is not my speed at all. I like it down slow. I guess i'm lucky i can kinda pick it up and sit it down when ever on more of a pain related basis than a recreational choice. If I just want to get high and escape I've found that Soma alone will scratch the itch and not nearly the physical dependence and addiction that benzo or Opiod use leaves me in. I guess I don't like tapentadol just enough to not want to abuse it, but enjoy it when i do? Human Strange,.

 

[silver_lining]

I have been taking Tapentadol off & on for about years now. Not my favorite opiate, but a damn good one when it comes to pain. Recreational use is a bit strange, I find it best used with Soma & Valium as by itself I find it quite speedy, which is not my speed at all. I like it down slow. I guess i'm lucky i can kinda pick it up and sit it down when ever on more of a pain related basis than a recreational choice. If I just want to get high and escape I've found that Soma alone will scratch the itch and not nearly the physical dependence and addiction that benzo use leaves me in. I guess I don't like tapentadol just enough to not want to abuse it, but enjoy it when i do? Human Strange,.

200 mg Tapentadol, 350 Soma, 20 Valium was my midnight snack a few nights ago. All at once. Lots of nods, lots of blackouts, ended up at a Casino playing Texas Hold'em and won $200 lol then nodded and was in bed. Horrible HR, sticking to Soma and Hash for a bit, maybe the occasional Benzo & a bath, that's nice.

 

[Azed]

200 mg Tapentadol, 350 Soma, 20 Valium was my midnight snack a few nights ago. All at once. Lots of nods, lots of blackouts, ended up at a Casino playing Texas Hold'em and won $200 lol then nodded and was in bed. Horrible HR, sticking to Soma and Hash for a bit, maybe the occasional Benzo & a bath, that's nice.

Man oh man. I loved the combination of tapentadol, soma, and clonazepam. I substituted the clonazepam with diazepam or bromazolam and it just wasn't as good. I normally just blackout watching YouTube videos and wake up an hour or two later confused as hell about what I'm watching haha.