The DXM Buck Stops Here.
^ I concur. Furthermore, because the DXM and MDMA reciprocally inhihbit the action of debrisoquine hydroxylase (CYP 2D6) [1], this can lead to excessive dehydration, uncomfortably strong effects and long durations, and awful comedowns and hangovers as a result. All that plus risk of SS doesn't make for a nice mix of drugs IMO.
Junglism posted "
when i have been on dxn its given me a happy feeling during and after to trip. so i guess it wouldn't over power the mdxx if kept in low quntities. and dangerous i dont think so but i dont know ??" -- there's a great DXM FAQ [2] if you want to read up about DXM drug interactions and reasons why
NEVER to mix it with MDMA. Essential DXM reading for anyone wanting to use DXM recreationally IMO.
However, in my opinion, the Durex/Safe Sex pills were MDMA only. This statement is backed up by quanitative results from the pink sample of Biscuit, plus a plurality of qualitative pillreports describing characteristic purple-to-black Marquis reagent results, and 'textbook' strong MDMA-like effects which appeared at the time these pills were circulating. Comments such as "
I am 99% sure that the blue (and probably [?]
other colours) Safe Sex pills had a bit of DXM in them. One dealer was telling me that it was a 9 parts mdma to 1 part DXM", I find extremely unconvincing and baseless, and without EZ-test results to support these claims they must be dismissed as guess work. This comment: "
Every single person who I saw took blue and yellow SafeSex/Durex acted like they were on a mdma/dxm combination," I'm not even going to touch. There is a wealth of testing results on safe sex pills that indicate MDMA only, and a high dose, which is corroborated by the quantitative results of the pink batch. The similarity between batches which was apparent should allow us to put the DXM issue aside.
One further point on the following comment: "
Now I keep away from all DXM pills because I post load with prozac (nowadays Zoloft) and if you have mdma (a MAOI) and dxm (a MAOI) and prozac (a MAOI) you get the badest mother fucking headache for days after." At its root, this quote has the right idea, in that DXM should NEVER be administered in conjunction with an MAOI. Neither should MDMA. Moreover, DXM should never be taken in conjunction with SSRI anti-depressants, and this can be a limiting factor with MDMA too. However, the quoted comment is factually incorrect.
Note that there is considerable confusion among drug users about what is and isn't a MAOI. MAOIs include a few drugs prescribed for depression and Parkinson's disease, and a few rare recreational drugs derived from exotic plant sources (harmine and harmaline, from Syrian Rue and Yagé, for example). Prozac, MDMA, cheese, beer, Seldane, etc., are NOT MAOIs - they are things to avoid when taking a MAOI. [3]
It can be very easy to confuse an MDMA reaction with a DXM reaction to EZ-test, particularly for someone who has never seen a pure DXM reaction, and is testing strong MDMA pills (such as the Durex/Safe Sex), because the colour change through purple can be too fast to observe and the reaction CAN be violent enough to cause bubbling. The development of bubbles and a colour change to black is
NOT sufficient to indicate a positive DXM reaction -- the hallmarks of DXM are a
slow change through grey (not purple) to black, over about 5-15sec, and the evolution of white gas bubbles.
As Pleo said, DXM pills used to be more frequent in the USA, and in 4 years of reading pill-testing results and testing pills myself, the number of confirmed DXM pills I have seen in Australia is vanishingly small. That doesn't mean we should ignore the possibility, but in the face of such overwhelming evidence (incl. quantitative analysis) against the possibility of DXM being in Safe Sex pills,
in my opinion DXM can henceforth be excluded from this discussion.
In the face of quantitative results, there should be no need to employ guess work. Let's get back to the real topic of the quantitative test results.
BigTrancer
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[1] - Generally speaking, inhibitors of P450-2D6 include antidepressants (both SSRIs and tricyclics, and possibly MAO inhibitors), antiparasitics (especially antimalarials), antihistamines (both prescription and over-the-counter), neuroleptics, beta blockers (drugs for high blood pressure), and antineoplastics (anti-cancer drugs). Methadone is a P450-2D6 inhibitor, and it is likely that many alkaloids, especially of plant origin, may be mild to moderate P450-2D6 inhibitors.
:- Source: The Vaults of Erowid --> DXM Vault --> DXM FAQ --> Appendix 1: P450 Inhibiting Drugs
[2] - Erowid DXM FAQ
[3] - DXM should not be used (either recreationally or at normal dosage levels) by people who are taking a monoamine oxidase inhibitor (MAOI) - either a prescription MAOI or a recreational one such as harmaline.
:- Source: The Vaults of Erowid --> DXM Vault --> DXM FAQ --> 4.16.1 Fatal or Dangerous Interactions
