I might be trying some anti-anxiety meds with some MAOI action. Does the danger of mixing mdma and meowies only apply when taking them on the same day or any time I'm enjoying any effect from a meowy? Basically, I'm asking how far apart must they be or if this isn't an option altogether.
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Question about MAOIs
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What medication would be the first question?
I’m not sure if I can think of any that have some MAOI action, typically they are or they aren’t.
As far as mixing, they need to be separated by at least 14 days and that’s not an option. Absolutely do not mix them.
I’m not sure if I can think of any that have some MAOI action, typically they are or they aren’t.
As far as mixing, they need to be separated by at least 14 days and that’s not an option. Absolutely do not mix them.
I'm experimenting with several Russian anxiolytics but I just realized that several of them are meowies or act as such so I wanted to know in general how carefully I must tread. The one I'm currently looking at is Mexidol and the following text seems to describe it as having some low key meowy effects.
What's this reversible/irreversible jazz?
What's this reversible/irreversible jazz?
Irreversible means the effect is permanent or what? You say drugs either are or aren't MAOIs but it says there the composition of Mexidol led to a "significant reduction in the MAO-inhibiting action" of the Mexidol prototype. I get the impression the drug is still a meowy but a weak one. What do you think?
Okay so I am curious what the fuck a meowy is lol.
As far as irreversible, it binds the enzyme permanently so it won’t be effective until your body produces more of the enzyme which takes time.
Reversible is competitive inhibition that can be reversed by increasing substrate or the drug unbinding from the substrate. Inhibition length can last a long time even though the drug half life isn’t that long.
It’s been a long time since I really read up on these topics but in reality it’s probably not enough inhibition to present a life or death risk. That said, I still would never advise attempting it.
As far as irreversible, it binds the enzyme permanently so it won’t be effective until your body produces more of the enzyme which takes time.
Reversible is competitive inhibition that can be reversed by increasing substrate or the drug unbinding from the substrate. Inhibition length can last a long time even though the drug half life isn’t that long.
It’s been a long time since I really read up on these topics but in reality it’s probably not enough inhibition to present a life or death risk. That said, I still would never advise attempting it.
meowy = MAOI. 
But since it's inevitable for the body to produce the enzyme then the effect is practically permanent right? The maoi never leaves your body?
A bad trip is enough to deter me, let alone a death risk so should I just avoid Mexidol altogether?
While we're at it, are any of these risky?
Adaptol (Mebicar)
Anaprilin (Propranolol)
Mexidol
Pantogam Active
Picamilon
Selank (I already took this one but I ran out)
But since it's inevitable for the body to produce the enzyme then the effect is practically permanent right? The maoi never leaves your body?
A bad trip is enough to deter me, let alone a death risk so should I just avoid Mexidol altogether?
While we're at it, are any of these risky?
Adaptol (Mebicar)
Anaprilin (Propranolol)
Mexidol
Pantogam Active
Picamilon
Selank (I already took this one but I ran out)
Phobos
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Given the low potency of those meds, you may not die quickly, and you may not even die at all, but the potency of MDMA will be increased together with its neurotoxicity and risk for serotonin syndrome and seizures.
There are no studies or even anecdotal experiences on the MDMA+Russky MAOI combo AFAIK, please do not be the lab rat.
You may die, suffer permanent brain damage, go into delirium, have seizures, or there is a small chance you will not.
Don't try it.
If you do go ahead, which you shouldn't, don't you dare take a full dose, your chances will be greater on a very low dose, like 50mg or less.
You may still die, and you should not do it, but it will possibly increase your chances, impossible to know by how much.
If you do it, don't do it alone and be in a place where an ambulance can get to you quickly.
But seriously, DO NOT DO IT.
There are no studies or even anecdotal experiences on the MDMA+Russky MAOI combo AFAIK, please do not be the lab rat.
You may die, suffer permanent brain damage, go into delirium, have seizures, or there is a small chance you will not.
Don't try it.
If you do go ahead, which you shouldn't, don't you dare take a full dose, your chances will be greater on a very low dose, like 50mg or less.
You may still die, and you should not do it, but it will possibly increase your chances, impossible to know by how much.
If you do it, don't do it alone and be in a place where an ambulance can get to you quickly.
But seriously, DO NOT DO IT.
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I appreciate the concern for my wellbeing Phobos, thanks. I won't do it together with any MAOI, but are you saying I still face these risks even if I roll say 2 weeks later as suggested by Swim15?
If I abstain from a potential MAOI for 2 weeks, you think the anxiety would come back? If it does, I resist the urge to roll because the comeup would fuck me up.
Hah, one bluelight user candyflipped with Afobazole which made me write that Russian drug off. I wonder if it's stronger or milder meowy than Mexidol.
If I abstain from a potential MAOI for 2 weeks, you think the anxiety would come back? If it does, I resist the urge to roll because the comeup would fuck me up.
Phobos
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The thing is, there are "suicidal" MAOI, that when they bind with a MAO molecule, they do so irreversibly, and that molecule is gone forever, so the number of MAOs in your body is lowered by each dose.
Your body tries to catch up, and will produce new ones, but it takes about 2 weeks from the last dose to have a normal level.
Then there are reversible MAOIs, that will temporarily bind to and deactivate a MAO molecule, and then let it go, so some time after last dose all the MAOs that were blocked are free to work as normal.
How did the Afobazole candyflip go?
I see. Thanks for the info. I won't do this but just a technical question, would candyflipping with a maoi and a low dose mdma (say 50mg) amplify only the negative effects of mdma or the positive ones too?
Russian 'novelties' - Fabomotizole, Mebicar (anxiolytic), Mesocarb (dopaminergic)
I though I would revive this one since I started researching all these "novelties" in varying dosages and combinations. There will be more to add, also ask any questions if you like, I can translate papers from Russian. I would like to add that Fabomotizole (Afobazole) definitely has something...
www.bluelight.org
Snowy_Hell
Bluelighter
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I used too mix St. John's Wort with MDMA and speed, but would always approach serotoninergic syndrome, almost dying from it three times. It's not fun to have your brain cooked on >40°C.I see. Thanks for the info. I won't do this but just a technical question, would candyflipping with a maoi and a low dose mdma (say 50mg) amplify only the negative effects of mdma or the positive ones too?
Russian 'novelties' - Fabomotizole, Mebicar (anxiolytic), Mesocarb (dopaminergic)
I though I would revive this one since I started researching all these "novelties" in varying dosages and combinations. There will be more to add, also ask any questions if you like, I can translate papers from Russian. I would like to add that Fabomotizole (Afobazole) definitely has something...
What was the mdma dose? My social worker recommended St. John's Wort to me once but I chose 5-HTP over that.
Snowy_Hell
Bluelighter
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5-HTP over MAOIs anytime. About the dosage, I can't really say since I've been snorting it throughout the night, but a gram went away in about 6 hours.
This lol.
is your comeup that bad? I’ve had one out of all my rolls where I had an incredibly bad anxiety attack and thought I was going to die for about 5-10min. But even then, I’d still say rolling is well worth going through that imo. Especially when you know logically you won’t die from a 150mg, or whatever, dose.