*skhnoorrfhghkh!* acid reflux..good one.
Although acid reflux sucks kitten-microwaving rotting paedophile arses. I suffer from it terribly. To the point where I'm now on at least 7 different meds for it, and those are just the ones I can remember off the top of my head.
So far, theres scopolamine transdermally, the butylbromide quat of same, orally, a PPI, gaviscon, cyclizine, cimetidine and ondansetron. Used to be on ranitidine, but told my doc I wanted it changed to cimetidine so I could take advantage of its cytochrome P450-2D6/P450-3A4 inhibition and get more bang for buck out of my 2 morphine formulations and oxy script. He did do somewhat of a double-take and give me a rather strange look that I don't have in my dictionary of body-language to intelligible meanings so of course couldn't translate, but he did do what I asked him too, to quite considerable success too
Had to add the ondansetron recently too, due to the severity of the vomiting up of torrents of acid, and when theres no more acid-cookies in the bag left to toss, a nasty mixture of foam and bile. Gaviscon helps, when used with the PPIs and all the mountain of other pain-in-my-arsehole-to-remember meds, but only so much, because it in and of itself can cause me quite a bit of discomfort, due to the acidity in there reacting with the amount of base needed to neutralize it resulting in too much gas buildup in my stomach, causing distension, discomfort and on occasion pain. To say nothing of belch after belch after really very impressive indeed belch. Once I pop, so to speak, I just can't stop
After taking the amount of gaviscon needed when my dyspepsia and reflux starts kicking off badly, it just keeps coming, one after another after another, and theres nothing at all I can do to hold it back, it just comes out, regardless of the company or the setting. You ever watched the TV show 'the simpsons' solipsis? because fuck me diagonally with a rusty mink if it doesn't sound for all the world,exactly like homer's friend barney, the drunkard from moe's tavern, the way he does those long, loud reverberating 'yaarrrkkkkhhhh' kinda burps, that make his tongue stick out and vibrate, like a charging jihadist mujahid, if affected with terminal flatulence in the middle of it's battle-wail
Expect hydrolysis? lamentably, I've come to do just that. Only its of my stomach lining and throat. Its put me in hospital several times. More than one of them being traumatic in the worst kind of sense, when the stupid fucking cock-nibbling whorespawned anus licking pigfucking sewer-rat-bastards KNEW full damned well that I am physically dependent upon opiates, not through abuse or even recreational use (well, that too, sure, but thats just a side-dish, so to speak), but through having been put on and maintained on those opiates by my doctor prescribing them, and have been for years, and years, and more fucking years. They knew this, and knew that the scripts were all currently still issued and used, yet denied me all but shitty, utterly worthless doses of oral morphine (10s, 20mgs 12 hour XRs at that! bastards, completely ignoring me when I tried explaining the low oral BA of morphine, and that even at the high doses I am MEANT to be on, I cannot even get close to it being of use without concurrent enzyme inhibition by cimetidine, and preferably grapefruit juice also. Didn't even give me my godsdamned chlormethiazole. I had to rely on a (plastic...ick) measuring syringe stowed away with me in expectation that was going to happen again, and a small RBF of chlormethiazole base, eyeing the dose, as I hadn't my scale with me, and stuffing it up my damn arse in the ward toilets. No antacids, no PPI, not sufficient pain meds even to prevent me going into fullblown withdrawal. I eventually managed to have someone get me some, although still not even close to enough, after telling them they either get off their fucking arses and GET SOME, or I was going to get on the phone/my laptop, and damn well start ringing round/IMing until I found someone who would do me some heroin, and bring it right round and deliver it to my bedside on the fucking ward.
(I am not usually so..well...rude, and don't typically get in people's faces like that and stir up grief. But I won't take being treated like that. Fer' chrissake I was ON that ward because I'd near collapsed due to the acid reflux and vomiting HCl and bile, streaked with blood. Any doctor or nurse is going to know what happens to an opioid dependent patient when they suddenly have their drug or drugs stopped, once the last dose taken wears off. Not least amongst those effects is what? vomiting? noooo...surely fucking well not! There was me thinking it makes the world rain candyfloss and ice cold beer....)
At that my telling them that, they did actually do something, but like I said, not NEARLY enough. Got some oxy out of them, albeit a piss poor offering all the same. And they expected me to take anything they did give me orally too. Despite being able to watch my trying to take a mouthful of water and it going down for less than 30 seconds before shooting back up, and out, again.No, I'm not a rude person, and I don't like to see people rip into nurses, doctors etc. because they are trying to help heal those same people. But I do have my limits, I wouldn't take being treated like that much dog shit from anybody else, so there sure as shit is no special rules in play for the medical profession to be allowed to sit there and do their best to make me fucking miserable, and in doing so, worsen the very problem I was admitted to hospital for in the first place. I don't deserve to be treated like shit either, they don't, of course not, but like fuck do I! Bastards left me like that for a bit over three days, before anything got fucking done. Even tried to get away with refusing me a second tablet of the ondansetron they'd given me, when it simply rocketed back up into the barf bowl. Claimed I couldn't have another one, because they didn't actually witness it come up. Actually implied I'd faked the pill-sized white splatter on the edge of the puke bucket, that I'd swallowed mere seconds before, just because they were not actually in line-of-sight at the time. Again, had to kick off, because no way was I standing for that! not that I could stand mind you, the foetal position was demanding enough!. Did get a shot of the zofran IM though, as they could see I'd go at it all night if I didn't get my way in that particular instance. And I don't think it unjustified/unjustifiable either, not given the situation I was in, and way I'd been being treated in a way that a decent human being would never dream of treating a fucking half-dead rabid dog.
Regarding nitriles and their safety..Yeah, I thought as much. Acetonitrile, whilst it smells good enough, is known to produce toxicity if sufficient exposure occurs. Although it appears to vary a great deal between individual compounds. i think unless I ever get round to in-vitro testing and analysis on the cyano analog of chlormethiazole, I'm going to give it a wide berth, insofar as actually exploring it in vivo. I absolutely refuse to test ANYTHING on animals. Unless its testing the preference for one or other brand of animal chow, that is about the one and only test of any kind on any species that I am willing to tolerate. I don't keep animals in the lab either, unlike me, they can't give or refuse consent to be exposed to anything floating around in the air in there.