Limpet_Chicken
Bluelighter
- Joined
- Oct 13, 2005
- Messages
- 6,323
Certainly in hospitals, when treating cocaine overdoses, beta-blockers are absolutely contraindicated. Thats because all the released (nor/)adrenaline has to go somewhere before its metabolized by MAO, COMT etc. And the other beta receptor subtypes aside, that means alpha receptors, alpha1 receptors control vascular constriction/dilation and the flood of vasoconstrictive catecholamine neurotransmitters released ends up there, when the beta-blocker essentially clogs up beta-adrenoreceptors, removing what (although this isn't their actual function in the body) in essence, acts as a sink, binding some of that nor/adrenaline and thus preventing it from all going to the alpha receptors (alpha1 being the problematic one, as alpha2 is the autoreceptor and
alpha2 agonists actually lower BP, heart rate etc., clonidine being the best known example, and have a sedating and hypotensive rather than sympathomimetic effect)
But, if you can safely do it I'd test stopping, given its not for a cardiac problem, without the coke, first, and see if any withdrawals take place, before deciding to use.
alpha2 agonists actually lower BP, heart rate etc., clonidine being the best known example, and have a sedating and hypotensive rather than sympathomimetic effect)
But, if you can safely do it I'd test stopping, given its not for a cardiac problem, without the coke, first, and see if any withdrawals take place, before deciding to use.