Gabapentinoids Pregabalin - totally different drug when taken after food?

[candidsurprise]

It's surprising how pregabalin feels completely different if I eat a light meal beforehand. On an empty stomach it's an intoxicating, tense, manic and mildly psychedelic experience. With food it turns into a much longer lasting clear headed stimulant, with a touch of cognitive euphoria. Physical euphoria is higher on the empty stomach, but cognitive euphoria and feelings of wellbeing are significantly lower. I've repeated this experiment quite a few times, it's a consistent experience of mine.

 

[Jabberwocky]

I've abused Pregabalin for 3 and a half years, and I'm prescribed it now for nerve pain, and I've never ever experienced "intoxicating, tense, manic and mildly psychedelic" effects that you just spoke about. I've also never had an effect you describe as a "longer lasting clear headed stimulant, with a touch of cognitive euphoria" if taken with food. The max I was taking was 900mg per day but the effects don't really change after 600mg. Now I only take 150mg per day but sometimes order more to mix with opioids etc (which can be lethal so watch out). So what I'd like to know is, what doses are you taking? and are you definitely taking Pregabalin?

 

[nznity]

I've abused Pregabalin for 3 and a half years, and I'm prescribed it now for nerve pain, and I've never ever experienced "intoxicating, tense, manic and mildly psychedelic" effects that you just spoke about. I've also never had an effect you describe as a "longer lasting clear headed stimulant, with a touch of cognitive euphoria" if taken with food. The max I was taking was 900mg per day but the effects don't really change after 600mg. Now I only take 150mg per day but sometimes order more to mix with opioids etc (which can be lethal so watch out). So what I'd like to know is, what doses are you taking? and are you definitely taking Pregabalin?

It's very subtle, some ppl(like you) don't experience the euphoria at all.

 

[Jabberwocky]

It's more mildly drunk if you're lucky, which isn't...to my understanding of the word "euphoric".

That feeling would only be euphoric to someone who's never taken anything.

 

[candidsurprise]

It's more mildly drunk if you're lucky, which isn't...to my understanding of the word "euphoric".

That feeling would only be euphoric to someone who's never taken anything.

I have bipolar disorder, so that manic euphoric feeling for me is most likely related to that. I also get closed eye visuals from it too. It's definitely pregabalin, I've tried many different sources and suppliers. I get a vaguely similar effect from phenibut, but less manic and not as enjoyable. Oh I also lose the effects completely if I take it two days in a row. Every 3rd day seems to keep them.

 

[wirkdy]

I've abused Pregabalin for 3 and a half years, and I'm prescribed it now for nerve pain, and I've never ever experienced "intoxicating, tense, manic and mildly psychedelic" effects that you just spoke about. I've also never had an effect you describe as a "longer lasting clear headed stimulant, with a touch of cognitive euphoria" if taken with food. The max I was taking was 900mg per day but the effects don't really change after 600mg. Now I only take 150mg per day but sometimes order more to mix with opioids etc (which can be lethal so watch out). So what I'd like to know is, what doses are you taking? and are you definitely taking Pregabalin?

hi mate nerve pain patient here too unfortunately

Can you please tell me how are you coping with nerve pain? for how long have you been suffering? is pregabalin really an effective cure?

I tried it but really can't bare it so much that prefer little heroin to relieve pain and I switched to vitamins and other supplements as a cure, I'm a little disheartened so I'd like to hear your experience.

 

[Lil'LinaptkSix]

Yeah pregab give me a drunken feeling and like I smoked a doobie on top of it. Also I get "shaky" if taking 300mg or above. After a couple years on pregab (at 100mg twice a day) it still gives me a "buzz" as I do not take it every day. I take kratom too so that helps also with the "high".
Eating fatty foods before or after definitley increases the effects. seems the more I eat the "higher" I get. Strange drug, IMO.
Come up time between eating and not before/after dose is not remarkable enough to remark on it. lol
Just my experienes.
Best wishes and be safe?
Peace

 

[yubacity]

Always take on empty stomach i finally quit after couple of years on it but today done 600 mg and im feeling it finally ate now was hungry but it fucks the buzz up

 

[Jabberwocky]

hi mate nerve pain patient here too unfortunately

Can you please tell me how are you coping with nerve pain? for how long have you been suffering? is pregabalin really an effective cure?

I tried it but really can't bare it so much that prefer little heroin to relieve pain and I switched to vitamins and other supplements as a cure, I'm a little disheartened so I'd like to hear your experience.

Hi mate,

I've had nerve pain in my left calf for 20 years from an accident. I've got nerve pain in my left shoulder from 2 failed operations on a left bankhart repair (torn), and I've got nerve pain in my left arm as the result of cortisone steroid injections from a pain specialist that was supposed to make my shoulder better but actually introduced a new problem. The way I manage it, though not fully, is 150mg Pregabalin, 10mg Amitritilyne and 200mg Tramadol per day. This combination honestly provides the best relief for me personally. However, you should be aware of a couple of obvious things which you may or may not know: once your body has got used to these drugs, particularly the pregabalin, it is extremely difficult to come off of..even with the tiniest increments in a taper this shit does wild things to your brain like voodoo and you wouldn't believe the consequences of trying to come off of it. But, my nerve pain was beyond being manageable with any one or two of the other meds I mentioned so I will be on them for life. My physiotherapist told me even the smallest of nerve damage can take up to 9 years to heal. I'm 42, and I've got it in 3 places..so I aint stopping these meds for love nor money. I would honestly suggest trying low dose amytritilyne first, that works for a lot of people, 10mg is really low, I was on 50mg but brought it down. I should mention I had chemo last year and that made everything worse, so I know even more definitely that I won't be stopping the meds.

Hope at least one piece of information gives you one progressive thought.

All the best!

S.A

 

[candidsurprise]

Always take on empty stomach i finally quit after couple of years on it but today done 600 mg and im feeling it finally ate now was hungry but it fucks the buzz up

That's interesting because my experience the opposite. If I take it on an empty stomach I get shaky like the other poster said, and I have this weird feeling of inner tension which ruins the benefits.

 

[yubacity]

That's interesting because my experience the opposite. If I take it on an empty stomach I get shaky like the other poster said, and I have this weird feeling of inner tension which ruins the benefits.

I just dont feel it much if i have eaten it so bad im one of the few that loses weight on pregabalin i might not eaty for a few days until tolerance has built so much it makes no difference if eat or not

That's interesting because my experience the opposite. If I take it on an empty stomach I get shaky like the other poster said, and I have this weird feeling of inner tension which ruins the benefits.

 

[candidsurprise]

I just dont feel it much if i have eaten it so bad im one of the few that loses weight on pregabalin i might not eaty for a few days until tolerance has built so much it makes no difference if eat or not

How often do you take it? If I take it for 2 days in a row, I seem to lose all the good effects. So I always leave 1-6 days in between doses.

 

[yubacity]

How often do you take it? If I take it for 2 days in a row, I seem to lose all the good effects. So I always leave 1-6 days in between doses.

I take them once a week now i you are right past day 2 it loses its value because of tolerance. I was taking at one point 60 300 mg a day 15 just to start the day 31 years i had been using and even 10 years of continuous meth use did not mess me up as much as pregabalin nearly destroyed my kidneys mind was gone . Once a week is good you will not get addicted I can do a heroin wd standing on my head but a pregabalin wd scares the fuck out of me

 

[candidsurprise]

I take them once a week now i you are right past day 2 it loses its value because of tolerance. I was taking at one point 60 300 mg a day 15 just to start the day 31 years i had been using and even 10 years of continuous meth use did not mess me up as much as pregabalin nearly destroyed my kidneys mind was gone . Once a week is good you will not get addicted I can do a heroin wd standing on my head but a pregabalin wd scares the fuck out of me

You took 60 x 300mg per day?! I'm surprised that didn't kill you, I've never heard of anyone taking that much

 

[plumbus-nine]

How on earth can one abuse pregab for years? I was prescribed it twice, first time 300mg were like being drunken, first time 900 I got all this manic dissociative goodness and I am not manic by nature. But after some time of 600mg/d all the effects were gone for good. Up to 2g nothing, then a grand mal like seizure. You are lucky to survive 18 fucking grams...

But what might answer the OPs question is that pregabalin gets actively transported into the blood by a transporter in the gut, so taking it with a meal will change the absorption.

 

[yubacity]

You took 60 x 300mg per day?! I'm surprised that didn't kill you, I've never heard of anyone taking that much

That was the highest i went i had brought indian signuture pregabs for 50 p each had tousands of them i would wake in morning take 15 300 mg straight off then through the day take 4 more packets of 15 300 mg . I was getting off the heroin and it took that much to help because i have been using them since i first stopped heroin in 2018 .When i pissed in toilet it had a head on it like beer my joints hurt felt like i had water on the lungs and in morning i could hear water moving in body my eye lid had swelled with fluid rough time got of it with 6 month taper and diazepam

 

[yubacity]

It's more mildly drunk if you're lucky, which isn't...to my understanding of the word "euphoric".

That feeling would only be euphoric to someone who's never taken anything.

I get euphoria on it if tolerance low and it the best drug to listen to music to but i know some people who feel nothing

 

[candidsurprise]

That was the highest i went i had brought indian signuture pregabs for 50 p each had tousands of them i would wake in morning take 15 300 mg straight off then through the day take 4 more packets of 15 300 mg . I was getting off the heroin and it took that much to help because i have been using them since i first stopped heroin in 2018 .When i pissed in toilet it had a head on it like beer my joints hurt felt like i had water on the lungs and in morning i could hear water moving in body my eye lid had swelled with fluid rough time got of it with 6 month taper and diazepam

I'm glad you got better man, that sounds like a horrible situation to be in. What I'm doing is alternating pregabalin and phenibut. So it's like this: pregabalin day, nothing day, phenibut day, nothing day, and repeat. Seems to preserve the pregabalin effecrs

 

[candidsurprise]

How on earth can one abuse pregab for years? I was prescribed it twice, first time 300mg were like being drunken, first time 900 I got all this manic dissociative goodness and I am not manic by nature. But after some time of 600mg/d all the effects were gone for good. Up to 2g nothing, then a grand mal like seizure. You are lucky to survive 18 fucking grams...

But what might answer the OPs question is that pregabalin gets actively transported into the blood by a transporter in the gut, so taking it with a meal will change the absorption.

I get that manic effect too. Apparently it signals some kind of latent bipolar issues

 

[yubacity]

I'm glad you got better man, that sounds like a horrible situation to be in. What I'm doing is alternating pregabalin and phenibut. So it's like this: pregabalin day, nothing day, phenibut day, nothing day, and repeat. Seems to preserve the pregabalin effecrs

You are basicly doing what i am i goit phenibut aswell always leave a day or 2 between phenibut use it also has a nasty wd which pregablin can mask completely . I always leave 5 or 6 days for pregabs because im so scared of their wd today i smoked heroin and now snorting coke. It partty time this weekend with pals so crack heroin today tommorow and today phenibut on sunday pregab on Monday . Then nothing for 5 days . Now a 300 mg capsule of pregablin gets me leave gaps for pregabs to work also phenibut handy for pregab wd dont completely mask it but helps