Hi new folks
Anyway try 4-FA?
Whats your tolerance like with other amphetamines?
Opinions, thoughts, dosage, etc. (yes I've been reading through the thread in OD, i just trust you PD guys. Its a family in here)
I've tried it a couple time but in sub-5-HT releasing doses (~20mg) or so. Feels like racemic amphetamine.
In the past couple weeks I've had lots of experience with 3-FA and 2-FMA.
3-FA: Pro; Clear, cerebral, high energy, good for studying. Con; long lasting, insomnia +12 hours.
2-FMA: Pro; Clear, calming, actually anxiolytic, good for studying. Con; long lasting (not as bad for insomnia as 3-FA), lacks that energetic, motivational boost. Thus, it's not very recreational but far less side effects than the 'meth-lite' 3-FA. It has a remarkable anxiolytic, calming effect than has been deduced to not the 5-HT release mediated (people who tried blocking it with SSRI's, found that it remained, unlike the MDMA effect.)
The 2-F(M)A anxiolysis is currently unexplained and I'm highly interested in finding out how it works. It doesn't give serotonin depletion and it's the only amphetamine I've ever had in me when I noded off in a lecture (only once, in the morning, and I was tired). Yet, it is focusing like other amphetamines and is a good study aid.
I haven't tried 2-FA yet due to lack of availability, but the N-methyl on these fluoroamphetamines doesn't seem to change things much. 3-FA is WAY more stimulating than 2-FMA.
Beware of current 2-FA supplies; apparently a large wholesale batch ended up being 4-FA; hence the 2-FMA thing.
I gotta do a bit of 4-fa reading here soon as I will have that to play with tomorrow afternoon. It has some serotonin properties so I'm excited to see if it has a little bit of a methamphetamine feel, though maybe getting 2-fma would have been better if I wanted something more similar to meth.
Nope! Read up on 3-FA.
Not sure what all the electron WD halogen does to its pharmacodynamics and pharmacokinetics besides that fluorine is going to be the less potentially neurotoxic halogen substitution on the aromatic ring F>> Cl > Br > I. Its probably going to not have some of the nasty metabolites due to low reactivity of a 1-(para-fluorophenyl)-propan-2-amine. The fluorine will have the electrons tightly packed around it (from it self and the aromatic ring), leaving the aromatic ring with an avg low density of electrons, diminishing reactivity of the ring as a whole. It isn't as reactive as the other halogens which I believe are parahydroxylation, while the flourine is not. Cl, Br, and I are more reactive and can be substituted via this way. Apparently this means that 4-fluoro will be less serotonin releasing than its other halogen counter parts though, but this may play a role in neurotoxicity so it could be good. I'lll have to do more reading of course
I've done a good amount of reading on the subject and the C-F bond is super strong, and these fluoroamphetamine regioisomers are supposedly fairly low on neurotoxicity. 4-FA being the worst due MDMA mechanism 5-HT release. As for general fluorine metabolism; the amount in small, we take in lots more fluorine from other sources; so far I've read the consensus to be that the fluorine atom is not a bad thing.
Like you said; it's the other halogens that are bad news. Guess why we only see fluoroamphetamines being sold and consumed.
So far I'm quite intrigued by this class; a vast improvement in effect profiles over 'traditional' amphetamines, besides for 3-FA's propensity for insomnia. The N-methyl homologues don't seem to change effect profiles much, which is neat. 2-F.. are anxiolytic but not serotonergic, also neat.
One thing that also stands out like crazy; low potency. IME 2/3/4-FA require 4 times the quantity to reach the same level of stimulation of regular amphetamine (ie. 40mg of 2-FMA for 10mg amp effect)
I haven't had a chance to really try 4-FA in proper dosage for real effects, I can't have low 5-HT right now and I don't have time for fun. Soon though.