yeah, I won't shoot coke anymore unless I have something for the comedown (dope or benzos). The comedown from a night of shooting coke is pure and utter hell which I can't deal with anymore.
I thought that the coke comedown wasn't anywhere near as bad as Amphetamine comedown, until I began to inject Cocaine for marathon amounts of time (8-12 hours straight of fixing and shooting a shot of Cocaine after a shot of Cocaine).
There is a study done on whether Methadone maintenance patients or people who are dependant/addicted to opioids get 'higher' from Cocaine than someone not dependant/addicted to opioids. Apparently Heroin addicts, MMT patients, etc all respond more favorably to Cocaine than someone without an opioid dependancy/addiction.
However, I can say from a lot of [painful] experience, that while on Buprenorphine maintenance and Methadone maintenance, that no amount of Buprenorphine or Methadone following a stimulant binge of any kind (but specifically IV Cocaine marathons) will kill or even soften the comedown. Why this is I don't know. However, while a Heroin addict and engaging in this auto-Cocaine-fever behavior, a small or moderate shot of Heroin completely erased all presence of comedown, cravings for Cocaine, all of the physical symptoms, etc.
Safety wise I don't doubt the severity of what you are putting your body through. Amping it up with huge amounts of Dopamine and Norepinepherine, Cocaine/Ecgonine, followed by an immediate intravenous redlight reversing everything in the blink of an eye.
I imagine it'd be like driving your car at 80mph in 4th gear, pulling the emergency brake and throwing it in reverse at the same time.