Hi,
I would like to post some advice and my experience with this substance. I have read quite a bit of misinformation about the drug and having done a search for the drug on Bluelight, I find that there are a lot of users who are making bad decisions with regards to using it.
I have used the drug for over 2 years on and off and only got myself addicted to it once as it served as an awesome AD during a tough phase of my life.
These are the points I would like to add (there are sub-sections to the points for ease of read):
1) Tramadol has two main problems with regards to using: its seizure risk and the danger of combining with other drugs.
- Seizure risk: it is impossible to predict when you will seize. Some people can use over 400mgs without a hint of seizing activity whilst others can go down on much less. Tramadol not only reuptakes norepinephrine but is also a GABA antagonist and "could" be a delta opiod agonist which in high doses causes convulsions.
Whilst seizures will occur when least expected, you should know when you are approaching seizure risking doses when you experience your limbs twitching/jerking. Do remember that even when most of the Tramadol is converted to the o-desmethyl version, you are STILL at risk of seizures as the metabolite has NE reuptaking properties (which is why it is difficult to fall asleep despite you may feel you are nodding).
- Drug combinations: Tramadol should not be mixed with anything that involves the serotonin or norepinephrine systems. This is a general recommendation and there are exceptions to the rule, but for any newcomers to the drug, you should avoid these. I am tired of reading Shambles scaring everyone of serotonin syndrome when combining Tramadol with serotonergic drugs but he does so for a reason. Please do also refer to point 2 for further information.
Lastly, it is a good idea to always use
www.drugs.com interaction checker.
2) Tramadol is not an SSRI nor is it a SNRI!!! Tramadol is a norepinephrine reuptaker and it is a
serotonin releasing agent not a reuptaker and by default it is also a mild serotonin reuptaker! This means that it will cause serotonin syndrome instead of blocking the effect of drugs such as MDMA or LSD. This is extremely important to emphasise as I read people giving recommendations based on the belief that Tramadol is a SNRI or even worse, an SSRI. Tramadol SERT releasing properties together with NE reuptake is why it feels like low dose MDMA the first few two hours of use. For references to the claim of Tramadol being a releasing agent please check Wikipedia's entry which everyone should be doing before using Tramadol. Check references 6,7,8,9.
3) Tramadol is an incredibly effective AD. I find that it will provide the best mood lift the first two hours of use which is when it is most active as a NE reuptaker and SERT releasing agent. I do not personally like the o-desmethyl mu agonist phase but all in all, Tramadol's mixed mechanisms of action is what makes it such an increible substance. It is also a BITCH to withdraw from and it is best used smart and seldomly to enjoy its effects. To me, 150mgs to 200mgs with about 100 mgs of caffeine (in the form of sugar-free red bull) is an awesome pick me up in the morning and will give you an smile no matter what.
4) Always dose Tramadol on an empty stomach, especially if you enjoy the fast come-up.
5) Those who bash Tramadol and think of it as a kid's drug could not be more wrong.
- In general, these people tend to be those with a high tolerance to opioids OR stimulating substances (such as cocaine). I can assure anyone with a tolerance to these drugs that if they dosed a gram of Tramadol they would feel why it is such an awesome substance. However, dosing a gram of Tramadol is extremely dangerous and unsustainable.
- People expect Tramadol to be a drug that hits you like a hammer like an Oxy would. NO, Tramadol is more of a subtle experience with mood lifting and charming properties. Nothing else, and this is why it is such an appealing drug to the masses. Those hardcore addicts looking for a smack replacer are in the wrong hole because they cannot appreciate the magnificient properties of Tramadol when looking to get high off their asses whilst withdrawing from heroin. To best appreciacte Tramadol, you should not have a tolerance and you should be in a not so negative phase of your life as WD is.
- There are people who are poor metabolisers of Tramadol into the o-desmethyl version (which provides the opiod effects) but everyone should be feeling the fast acting mood properties of the pro-drug Tramadol. Unfortunately, if you use an eight of cocaine everyday, you will not feel the mood lifting properties of 150mgs of Tramadol.
I wanted to oultined the above as I am tired of reading such misinformation being spread on forums about this substance as well as people bashing it. Of course, what I have stated is not written in stone and I am willing to discuss but I think we should really be focusing on giving correct available information to people as this is a substance that should not be played this. I mean, I just posted in a thread of someone using methamphetamine with Tramadol.
All the best.
