About a decade ago I took mushrooms with a rather new friend at the time and his girlfriend, whom I'd never met before. We took nitrous at the tail end of the experience. The girlfriend had never taken it before, and after she inhaled she began moaning a bit making some weird sounds. After that she was blushing a bit, and after a while she said, in a very embarrassed tone :" Eh... I think ...I just had an orgasm". Both me and my friend sat in silence for a few seconds, after I replied "eh, well, congratulations... I guess". My friend said nothing, just giving her a strange look.