I'm a big fan of UR-144. Its a strong full CB2 agonist with atleast 83x more affinity towards the CB2 receptors than the CB1. Yes at lower doses (its quite potent) you primarily feel a strong indica like high, but at higher doses there definitely is a mental side that has hints of dissociation. I have only two issues with it, one the timeline of the drug goes as follows for me, 10 minutes comeup, 30-45 minute peak, 30 minute comedown, and 30 minutes light residual high. So overall it lasts max 1.5 hours which is kinda annoying and tempts redosing.
I'm currently about to receive some AB-001, which I know nothing about and most reviews I read is that it is kinda weak, which really disapoints me and made me wish I didn't order it. I'll have to dig more into the research and see if I can find more reviews on it. If anyone has experience with AB-001 please PM and let me know what you know. Thanks.
I'm also curious how UR-144 and AB-001 would combine (I don't do blends but just would smoke a small quantity of each). I am going to wait on trying the AB-001 till I can find some information on the potency. I'd be happy if it would be like UR-144 and be active at the single digit mg range like UR-144, but reading on drug-forums, the only two posts commenting on the potency said it was relatively weak. Also, I've noticed UR-144 isn't active orally, at least at the doses I've consumed it at (30-50mg oral) and I'm curious if AB-001 would be active orally.
I've used UR-144 (a full agonist at the CB2r with >= 83x the affinity of it's CB1 agonism) for 3 week everyday with no problems after stopping, then even 2 weeks later used UR-144 again for another 3 weeks with out stopping, with again, no problems after cessation of use. So I'm not sure quite what you mean, or if it needs longer duration of constant use. I don't mess around with cannabinoids to often, as they aren't a substitute for marijuana. I treat them like I do any other drug of a certain class of chemicals, and value them for their own unique effects profile.
I also prefer to not over indulge in cannabinoids as of course their health consequences are unknown. I'll try a new cannabinoid every so often and never as an attempt to find a new marijuana, as that honestly is an insult to the cannabinoids.