IV morphine always had the craziest histamine release for me, granted I'd use 200mg at a time but that feeling of having every inch of my skin from my taint to my scalp itch and sometimes get red and blotchy for 10 mins. Oxy seemed so much more user friendly.
That is why they have antihistamines %) (just had to point that out, you should have been prepared, although 200mg is a lot
Not convinced, or rather not sure what role Jappa plays in oxycodone; could explain why some people like it so much, yet buprenorphine is actually an antagonist at Kappa receptors, and oxycodone has a surprisingly low binding affinity(Morphine has binding affinity that is about 5x higher, oxymorphone >20x higher) so it would seem that would present a problem with ORT; it is interesting though and another study matching that would be hard to ignore (not ignoring that, interesting find, only saying it would be solidified with concurrence)
*on topic*
Seriously, it is diamorphine and morphine, IV
Can't believe anyone would take oxy or hydromorphone over the almost immediate bliss of good dope, talking h hydrochloride people
Morphine tends to have more/intense side effects, however those can be n gated, although you cannot quite match H's rush, you can come pretty close, and in the end, a high enough dose of morphine is pretty much equal-they also both good for a surprising length with proper dosing, and just make the body feel like it is swimming in opiates; good stuff(and wildly addictive)
and methadone is better than it is given credit for; with inhibitors a couple of doses can have you feeling swell for days
Tolerance comes into play, or so it seems; IRL, as people(users) tolerance grows, and especially if they get out of control, oxycodone seems to lose it's appeal, although that could be because it is(or at least was, haven't really done RC opioids in awhile) overpriced.
Though in general an IV user who can get it seems to move on to H, or so it seems
PO, morphine or methadone, depending upon the purpose, although if exotic opioids are available then would consider those, although if supply was not an issue, morphine and methadone, by mouth, and IV, although H tops Morphine Classic
Intranasal, oh who knows. Probably oxymorphone, really not a big nasal drug user, never really was, except if had oxycodone, and simply no point, well then if it was pure oxy would typically snort if practical, it was more euphoric, and hits fast and harder than PO, yet duration pretty much the same(both wear off so fast it still makes me wonder what it is that makes it so popular and expensive, not super fast, though it simply does not hold you like a good shot of morphine/diamorphine
Like the ratings, though, and the one poster who went into giving figures for duration, feeling, side effects and overall;
Ok done
Don't normally lurk this forum so excuse me, will be leaving as soon as my P-Wing is found
(The usual suspects better be cautious; anyone goes near my Frog suit and it's on!)
