Hi Ismene
Interesting rorthron, I find taking DMT in the salt form causes just as much nausea as the freebase. The only way around it is taking essence of lemon oil to help with the nausea.
I had this discussion some years ago at the DMT-Nexus many times. It was always like this: someone was complaying on how pharmahuasca would make them puke. And I always suggested them to add some vinegar until the freebase dissolved and without exception, for all who tried it, he nausea was always severely reduced. There are 2 types of nausea on DMT. The first one by taking the substance as soon as it arrives on the stomach and then after it starts its effects. The latter is a "brain induced nausea" like in sea-sickness. This is unavoidable, but passes quickly. The first nausea is quite avoidable or minimized if we take it salted.
Is lemon juice really so powerful that it can dissolve mushroom matter inside 20 minutes? And isn't psilocybin dephosphoryliated to psilocin almost exclusively in the liver? That's the whole purpose of the liver - to carry out those biochemical reactions. It's got to be processed by the liver however long you've soaked it in lemon juice - that's a physical certainty.
I'm not discussing the transformation of psilocybin to psilocyn, but rather the chemical release of psilocybin from the mushroom organic matter. When one does extractions like extracting DMT from mimosa, one always add acid (like vinegar, or HCl), to release the DMT that is bound to the tannins, and thus make it more readily soluble. If you do not do that, your yields will be dismal. With mushrooms, my guess is that the same thing may happen. Soak them with acid, release the alkaloids and ingest them. Returning to DMT. My extraction yields range from 1.2-1.5% DMT on mimosa root bark. This means that if I took 3 grams of raw mimosa I should get about 35-45mg ofd DMT. However to get a similar expereince to 40 mg DMT, I need *at least* 5 grams of mimosa, if ingested raw. Which, on DMT, confirms my theory that acid on the plant matter helps the extraction of actives and may facilitate a more ready absorption. Also, if you check on erowid, most recipes for mimosahuasca use... lemon!
It would be useful if you could make it double-blind. Mix some with lemon juice, some without lemon juice and then ask a friend to choose which ones to give you.
Interesting idea, but it would be difficult, as I believe I could track the taste of lemon or vinegar anywhere. So even if my partner in the experience did not know, I would in the second I would put in my mouth...
hmmm coming to think of it, there is a possibility. One could do 2 equal dosages A and B. A would just receive powdered mushies inside gelatin caps. The other, B would be the dried extract of a lemon or vinegar extraction. I would not be told what I receive and evaluate the experience for myself. And on another occasion take the other set of capsules ... Maybe this could work. With some other people doing that, one would be sure, and dispel, or not(!), an urban myth.