Some dissociatives like deschloroketamine seem to selectively mask / inhibit / suppress negative emotions in me. What initially felt like a win in the lottery turned against me, horribly. Over time (I was on it 24/7 for months) I lost perception for what's good for me and what not, who and who not, where to stop etc. and I slipped into the worst, self-destructive depression - I was depressed and self-destructive before this period of compulsive use though, and initially it was the single most fucking euphoric and dis-inhibiting experience I've ever had and maybe ever will have. Thrashed good part of my life and maybe neurological health (and this possibly not even from the dissociatives but from toxic by-products but this I'll never know for sure unless somebody else shows up who did even more of the same stuff and got even worse problems and those analyzed). Don't do it.
Besides that, I find opioids to be more numbing than dissociatives.
But is it really possible not to feel anything or will you feel that you don't feel and this' like shit?
Is it desirable?
I know, antipsychotics have the reputation of being emotionally numbing but they fail for me, altogether. They don't feel numb, but intoxicated, in a very bad way. Like I'd be going to die if they'd force me to continue on a high dose of this stuff, quetiapine is specially bad but all of them are toxic imho. D2 antagonism was a good theory but it was flawed and showed to be wrong - we have D2 agonists which not only don't worsen psychosis but can even aid with it (granted, memantine's the only one I know of, but opioids too increase DA throughput and are considered antipsychotics.)
