Methyl PMK-glycidate is the most popular MDMA precursor but produces (R)MDMA. After a lot of head-scratching, I was trying to work out why on one hand pills with 300mg+ of MDMA are regularly seized and yet users state that modern pills are 'wrong'. The route does not proceed via PMK; in fact, the synthesis is a single step. The reason why the EPMKG is chiral is that it is synthesized using a naturally occurring amino-acid.
Now there are several compounds that produce effects that are almost indistinguishable from MDMA and some of them are legal in most nations.
- (S) α-methyltryptamine (the (R) isomer is the hallucinogenic isomer so if you resolve this compound, you get 2 different products)
- 7-methyl-α-ethyltryptamine
- (S) 7,α-dimethyltryptamine (the (R) isomer is the hallucinogenic isomer so if you resolve this compound, you get 2 different products)
- 2:1 ratio of p/m aminorex
-m-methoxy-p-ethyl amphetamine
I have tried both the racemate & resolved isomers of AMT which is what got me interested in the subject. The 7-methyl moiety on the indole increases the serotonin release by an order of magnitude. Back in the 1960s AET and a series of related compounds were patented as antidepressants. The 7-methyl indole precursor is rather costly.
I do apologize for being somewhat vague, this was stuff I looked at 9 or 10 years ago. There are more but the synthetic complexity means they aren't great targets. I would be prepared to bet that p-Me phenmetrazine will have similar activity. Now I seem to recall a paper on methylphenidate analogues that were also seratonogenic. If memory serves the piperidine ring is a replaced by a pyrrolidine (1 carbon less) and the aromatic has a p-Me.
Now there are several compounds that produce effects that are almost indistinguishable from MDMA and some of them are legal in most nations.
- (S) α-methyltryptamine (the (R) isomer is the hallucinogenic isomer so if you resolve this compound, you get 2 different products)
- 7-methyl-α-ethyltryptamine
- (S) 7,α-dimethyltryptamine (the (R) isomer is the hallucinogenic isomer so if you resolve this compound, you get 2 different products)
- 2:1 ratio of p/m aminorex
-m-methoxy-p-ethyl amphetamine
I have tried both the racemate & resolved isomers of AMT which is what got me interested in the subject. The 7-methyl moiety on the indole increases the serotonin release by an order of magnitude. Back in the 1960s AET and a series of related compounds were patented as antidepressants. The 7-methyl indole precursor is rather costly.
I do apologize for being somewhat vague, this was stuff I looked at 9 or 10 years ago. There are more but the synthetic complexity means they aren't great targets. I would be prepared to bet that p-Me phenmetrazine will have similar activity. Now I seem to recall a paper on methylphenidate analogues that were also seratonogenic. If memory serves the piperidine ring is a replaced by a pyrrolidine (1 carbon less) and the aromatic has a p-Me.