One thing I will conclude based on current data is that if you do suffer significant organ damage from MXE abuse, you are clearly doing it wrong. MXE has blessed us with a large therapeutic window not seen in other drug of this class. The proper terminology, 'therapeutic index', is what we are trying to define in this thread. It is my view, based on my personal experience coupled with all external data, that MXE used in a way that both respects the power of the drug and achieves the maximum therapeutic and/or recreational potential requires dosage levels and durations in a range that reside well within this window of safe use as long as the user is grounded and of good mental/physical/spiritual health. Users of sub-optimal health attempting to remedy their health with the help of this drug will need to be much more careful, titrating up, dosing infrequently and ideally used with a grounded guide/therapist/shaman/buddy.
To respect the power of it is to appreciate a few things, but most importantly it is to allow adequate periods of rest and reset between trips/doses. This lets the body remain connected to base homeostasis while letting the experience soak in. From my experience, after a few concurrent days of doses, the potential for harmful disconnection grows while the potential for beneficial connections decreases.
MXE can be a great teacher of ancient wisdom and inner truth, but it takes time to let the ripples permeate one's consciousness. With sufficient 'off' periods, one can not only avoid tolerance and maintain appreciation but effectively decode and integrate the wisdom herein.
I'm not saying my past use has been within this therapeutic window. I certainly pushed past the limit of therapeutic and recreational benefit. I was stupid thinking i could maintain that quality of energy I enjoy so much. Luckily, the drug is forgiving enough to let me be here now and pass this information on so that future explorers do not have to test the limits of this window.