Asante
Bluelighter
- Joined
- May 4, 2012
- Messages
- 1,112
Research has been done as to the metabolites of Methoxetamine http://www.ncbi.nlm.nih.gov/pubmed/23774830 from which I quote:
The main urinary metabolite of Ketamine is dehydronorketamine, which is thought to be the primary cause of Ketamine bladder toxicity, due to it being an alpha-beta unsaturated ketone (a derivative of the toxic, alkylating irritant species cyclohexenone, or dehydrocyclohexanone).
The MXE derived analog of that irritant metabolite, dehydronormethoxetamine, was not identified in human or rat urine, and because of this, MXE likely does not demonstrate dehydrocyclohexanone derivative mediated bladder toxicity.
It still doesn't mean MXE is harmless of course, not by a long shot.
So I ask, is there anyone here who has never used ketamine but who used Methoxetamine heavily and has contracted the same degree of severe bladder toxicity as is common in regular Ketamine use? It is key that they never used Ketamine before, because this can have done dehydronorketamine-mediated damage which then might have been worsened by the MXE.
Eight metabolites were identified in rat and different human urines allowing postulation of the following metabolic pathways: N-deethylation, O-demethylation, hydroxylation, and combinations as well as glucuronidation or sulfation.
The main urinary metabolite of Ketamine is dehydronorketamine, which is thought to be the primary cause of Ketamine bladder toxicity, due to it being an alpha-beta unsaturated ketone (a derivative of the toxic, alkylating irritant species cyclohexenone, or dehydrocyclohexanone).
The MXE derived analog of that irritant metabolite, dehydronormethoxetamine, was not identified in human or rat urine, and because of this, MXE likely does not demonstrate dehydrocyclohexanone derivative mediated bladder toxicity.
It still doesn't mean MXE is harmless of course, not by a long shot.
So I ask, is there anyone here who has never used ketamine but who used Methoxetamine heavily and has contracted the same degree of severe bladder toxicity as is common in regular Ketamine use? It is key that they never used Ketamine before, because this can have done dehydronorketamine-mediated damage which then might have been worsened by the MXE.