Opioids Methadone

[Anthonysymington1967]

I highly doubt you would feel the dhc .

Highly doubt I would feel how much DHC?

 

[Anthonysymington1967]

Hi, I’m on 30mg methadone a day , I use to do upwards of 900 mg DHC dihydrocodeine a day , my question is would the 30 mg methadone block the DHC? If I did use DHC on top of methadone how much less should I use? Any advice would be appreciated , thanks

thanks for some of the replies , basically to be totally straight I used to take up to 900 mg DHC dihydrocodeine just to get a buzz, I’ve been off it for about 14 days now and on 30 mg methadone for about 6 days now, I was just wondering if I took my 30 mg methadone and then took maybe 300 mg DHC on top of that would I get a buzz? Would I fee the DHC at all? Would it be too dangerous? I be heard the blocking effect of methadone doesn’t kick in untill over 50 mg and I wouldn’t of thought 300 mg of DHC on top of 30 mg methadone would be too much considering my tolerance but was just wanting advice, I’ve had some answers but I’m not sure I had fully explained what I meant properly at first , many thanks

 

[Zonxx]

thanks for some of the replies , basically to be totally straight I used to take up to 900 mg DHC dihydrocodeine just to get a buzz, I’ve been off it for about 14 days now and on 30 mg methadone for about 6 days now, I was just wondering if I took my 30 mg methadone and then took maybe 300 mg DHC on top of that would I get a buzz? Would I fee the DHC at all? Would it be too dangerous? I be heard the blocking effect of methadone doesn’t kick in untill over 50 mg and I wouldn’t of thought 300 mg of DHC on top of 30 mg methadone would be too much considering my tolerance but was just wanting advice, I’ve had some answers but I’m not sure I had fully explained what I meant properly at first , many thanks

Nah you wouldn't feel it whatsoever. also the blocking effect is dependent on how 'susceptible' its not the right word but my brain isn't working right right now so lets go with that, susceptible to its effects. 10mg can have someone blocked depending on how their body reacts, i know im EXTREMELY sensitive to methadone in particular of all drugs, 1 lil 40mg cup'll block me for a week and that's while taking opiates afterward just trying to escape the pain
to be realistic, DHC isnt that strong, you'd need a solid dose of heroin or somthing
ps. the methadone 'buzz' builds up as you take the methadone it's similar to bup in that way, when given to pain patients as an example (if they have a history of substance abuse) it can take up to a week-3 weeks for the bup to start working for their pain and the levels build up
IF youre taking the methadone recreationally, id suggest against it in my experience it's even more gripping than IV heroin.
but alass, i'm going to be in the methadone boat somtime in 5 years and im not too happy about it

 

[Anthonysymington1967]

I’m taking the methadone as part of a maintenance treatment to keep me off the DHC as it was taking over my life, constantly looking for the money to buy it every day, so yes I know I shouldn’t go anywhere near it again but the addict in me just wondered if I would get any wee buzz at all. I’m surprised cos I’ve only been on the methadone for 8 days and I was told at the start that the starting dose they put me on which is 30mg wouldn’t touch me cos of the amount of DHC I’d been doing which was 900 mg every day of my life for years and on occasions 180 mg of morphine which wouldn’t touch me and for one week a fentanyl patch just worn as a patch like a normal user would, no cutting it up or chewing on it etc but it still scared the shit out of me,don’t mess with that stuff ppl.But actually the 30 ml of meth they started me on gets me kind of high in a way,a nice wee glow, like maybe 20 percent of what my 900mg DHC would of gave me . neither the DHC or morphine was ever injected btw, only ever tablets taken orally so I thought as I’d read there were ppl taking 45 ml of meth n taking heroin on top of that and still getting a buzz I might still manage a buzz off 300mg of DHC with my 30 ml of meth but I will take your advice and not bother. I was going to try 300 mg of DHC so 10 x 30 mg tabs and if I got nothing maybe a few hours later same again but never more than that even if I got no buzz at all bcos I’ve read that people keep taking more n more looking for that euphoria which bcos of the methadone never comes but the respiratory depression and death does.I just thought that being on such a low dose of meth, n having only been on it for just over a week I might still have gotten a little DHC buzz. Tbh I should be thanking god that as little a dose as 30 mg of meth seems to give me a glow and hold me,obviously it’s not taking away the cravings for DHC completely but I’m not sure if that’s just the addict in me always wondering or if maybe one more step up to 40 ml meth would take the cravings away,I have heard the “sweet spot” for meth users is often between 60 ml and 120ml and that the blocking part doesn’t kick in till at least 50 ml possibly 60 but I really don’t want to go up over 40 if I don’t have to and I’ve no idea if the story that the blocking part of the meth doesn’t kick in till a certain dosage like 50 or 60 ml is true and tbh I’ve heard how hard it can be to get off at any dose but especially when you get up over the 60. I’m just truly thankful I’m not gong through withdrawals and I’m not spending every minute of every day thinking how I can get my hands on pills, I got so bad I ended up taking meds from family(so ashamed) and that’s how i got caught and as painful as it was, it was a blessing in disguise, I then admitted to my mum about my 16 year pill habit that no one in my family or friends had a clue about, she agreed I’d i got help she wouldn’t press charges and she would support me. There’s online clinics over here in Europe that use legal loop holes that make it so easy to get hold of pain pills , they dirspense them from Uk pharmacies but use docs from eu but not full eu countries like Romania (not sure exactly how that works ) as much as they have been a god send to me in the past, they need to be shut down for a start! They are destroying ppls lives.I know I’m on here asking about if I could still get a buzz from DHC while on meth so I know I’m no angel and still have a long way to go but I’m hopefully on the right track and I’d rather ask the question on here and be a little safer than not. Truth is there’s more and better advice on here than from a lot of GPs tho I would always say go to your GP or medical practictioner first. Sadly here in I’m a lot of Gps attitudes are very poor, especially if it’s pills, if it’s illegal drugs so to speak lie cocaine or heroin and your injecting then they will try n help but if it’s pills it’s like you fall into a little crack and get missed out. That’s my story anyway, would like to here anyone else from uk views on that? Apologies for length of this message and if I’ve posted it in wrong bit etc , I’m just getting use to this and I would hope maybe a mod will let me know and correct me on anybmistakes I’ve made .again thanks for all the replies. I have no idea how this site works with private messages etc I just want to say if anyone is ever down or struggling and needs to vent or chat I’m always here and willing to listen, I apologise if that’s against any rules and again maybe down kids could help me out. Stay safe and god bless, thanks.

 

[Zonxx]

I’m taking the methadone as part of a maintenance treatment to keep me off the DHC as it was taking over my life liking for the money to buy it every day etc so yes I know o shouldn’t go anywhere near it again but the addict in me just wondered if I would get any wee buzz at all. I’m surprised cos I’ve only been on the methadone for 8 days and I was told at start that the starting dose they put me on 30mg wouldn’t touch me cos of the amount of DHC I’d been doing 900 mg every day of my life for years and on occasions 180 mg of morphine which wouldn’t touch me and for one week a fentanyl patch just worn as part which scared the shit out of me , but actually the 30 ml of meth gets me kind of high in a way, q nice wee glow, like maybe 20 percent of what my 900mg DHC would of gave me . neither the DHC or morphine was ever injected, only ever tablets taken orally so I thought as I’d read ppl taking 45 ml of meth we’re taking heroin on top of that and still getting a buzz o thought I might still manage a buzz off 300mg of DHC with my 30 ml of meth but I will take your advice and not bother. I was going to try 300 mg of DHC so 10 x 30 mg tabs and if got nothing maybe a few hours later same again but never more than that even if I got no buzz at all bcos I’ve read hat people keep taking more n more looking for that euphoria which bcos of the methadone never comes but the respiratory depression and death does. I just thought that being on such a low dose of meth , n having only been on it for just over a week I might still have gotten a little DHC buzz. Tbh I should be thanking god that as little a dose as 30 mg of meth seems to give me a flow and hold me , obviously it’s not taking away the cravings for DHC completely but I’m not sure for that’s just how he addict in me always wondering or if maybe one more step up to 40 ml meth would take cravings away, o don’t really want to go up over that as I’ve hear how hard it can be t get off , I’m just truly thankful I’m not gong through withdrawals and I’m not spending every minute of every day thinking how I can get my hands on pills, I got so bad I ended up taking meds from family and that’s how o guy caught and as painful as it was it was a blessing in disguise, I then admitted to my mum about my 16 year pill habit that no one in my family or friends had a clue about . There’s online clinics over here in Europe that use legal loop holes that make it so easy to get hold of pain pills so east they need to be shut down for a start! I know I’m on here asking about if I could still get a buzz from DHC while on meth so I know I’m no angel and still have a long way to go but I’m hopefully on the right track and I’d rather ask the question on here and be a little safer than not. Truth is there’s more and better advice on here than from a lot of GPs tho I would always say go to your GP or medical practictioner first. Apologies for length of this message and again thanks for all the replies. I have no idea how this site works with private messages etc I just want to state of anyone is ever down or struggling and needs to vent or chat I’m always here and willing to listen , I apologise if that’s against any rules and I would give any mods would maybe point out to me any errors I’ve made on this post. Stay safe and god bless, thanks.

How easy was it to obtain your methadone Maintnance therapy? inquiring because when my doc retires he's not sure if he can reffer me to another due to 'not many doctors want to take patients with your level of opiate use' (heavy user for chronic pain) fuck this epidemic, it should be legalized so that people can maintain themselves with their opiates of their own choosing instead of THIS OR THAT

 

[Zonxx]

also yes. there is better advice here, because drug addicts aren't stupid people, to the outside world they may seem to be but once you flip the page you understand everyones the same, when my non-drug friends ask about my crack or whatever usage (they dont ever ask about my pain meds because they know how bad it is) i ask them about their coffee in the morning or their alcohol consumption, in the end THEYRE ALL DRUGS just because somthing is illegal or because people are ODing on things doesnt change what they are in the end their still substances albeit different and everyone does what gets them through the day
but im fortunate enough to have respecting friends, even one studying to become a police officer that doesn't mind me smoking crack in his car, but i don't take my friends for granted but im always real with whoever i meet and i haven't ever hidden who i am, im extremely liberal towards substances used in moderation, i have no problem suggesting someone not use as much but to tell them not to is out of the book

 

[Nicomorphinist]

Yes the money is where the rubber hits the road with this kind of thing and I would assert that nearly all narcotics people and most of the others do not have a drugs problem per se but a supply chain and economics problem. Sort of like the medical student I knew who was a chartered accountant and local politician -- when his doctor was scared into tapering down his morphine, I get a call at 4.30 one morning where he said big trouble was brewing -- he was sitting in his car two blocks from a chemist's shop with a large spanner, a sledge-hammer, a tool box, a bottle of ether, two sticks of dynamite, and a BB machine gun with a cycle rate of 1350 shots a minute which he was going to shoot out the street lights and take out all the windows with. He was getting ready to dip his toe in the Rubicon and turn into a burglar, so a priest and myself took him with us to a methadone clinic and got him signed up. Then his lawyer started raising a stink about the non-consensual taper.

 

[Zonxx]

Yes the money is where the rubber hits the road with this kind of thing and I would assert that nearly all narcotics people and most of the others do not have a drugs problem per se but a supply chain and economics problem. Sort of like the medical student I knew who was a chartered accountant and local politician -- when his doctor was scared into tapering down his morphine, I get a call at 4.30 one morning where he said big trouble was brewing -- he was sitting in his car two blocks from a chemist's shop with a large spanner, a sledge-hammer, a tool box, a bottle of ether, two sticks of dynamite, and a BB machine gun with a cycle rate of 1350 shots a minute which he was going to shoot out the street lights and take out all the windows with. He was getting ready to dip his toe in the Rubicon and turn into a burglar, so a priest and myself took him with us to a methadone clinic and got him signed up. Then his lawyer started raising a stink about the non-consensual taper.

OH MY GOD FUCKING LOL YES. WOAH THIS. IT MADE MY DAY TY
the day my doc mentioned retirement, the following month picking up my meds its a smaller pharmacy run by chinese folks who dont speak great english, i was checking the doors, where the cameras were.. those windows are 4 whole inches thick i couldnt believe it but their back door isnt all that mighty muhahaha
Planned the perfect heist that day, highway is 6 blocks away, oh boy i cant believe how fucking relatable this is i love it thanks for sharing LOL day = made
But i know where all my opiates are on their shelves now too haha ive watched with great vigilence itd be an in an out job if it came to it

 

[Anthonysymington1967]

How easy was it to obtain your methadone Maintnance therapy? inquiring because when my doc retires he's not sure if he can reffer me to another due to 'not many doctors want to take patients with your level of opiate use' (heavy user for chronic pain) fuck this epidemic, it should be legalized so that people can maintain themselves with their opiates of their own choosing instead of THIS OR THAT

Here in Scotland you can self refer tmtoyrself to addiction services, your seen within 3 weeks normally by an addiction specialist nurse who will talk to you about your addiction, what your using and. What you want to do , if your wanting to cut down on your use of drugs or get off then conokuwtkey and then they will ask you if you feel you want to try maintenances, then they refer you to the addiction doctor , this part can take up to another three weeks or so and if they decide you need and you agree you want to be on methadone they will give you your script at that appointment and you take it to chemist and get started , first dose is always atm most 30 ml as that’s all they can safely at first but you will Have a nurse or addictions specialist who you will see evenly couple of weeks and if you call them n tell them it’s not holding you they can put it up at 10 mg every 4 days at most, Tuesday is normally the scripts are done so if you tell your nurse on the Thursday it’s but holding you you will normally why your new dose the next Tuesday, obviously as well as All this there’s groups and charities such as addaction who they prefer you to work with as I’m sure you know , methadone is all good but if your not going to work on the reasons behind your use it’s kind of pointless. Also if your I severe withdsawals when you first see them they can put you in to a detox but there’s very limited spaces , I was already in day 8 of withdrawal when I got my appointment so as painful as it was I just pushed through ,after my first appointment OJ day 8 of withdrawal I was told my appointment for the day is get the meth script would be 3 weeks away as they were so busy so you can imagine how depressing and scary that was. I sadly had a crisis about a week later and had a suicide attempt so was moved forward and seen quicker , I wildly suggest using it as a way to speed up process tho, certainly wasn’t what I was doing

 

[Zonxx]

Here in Scotland you can self refer tmtoyrself to addiction services, your seen within 3 weeks normally by an addiction specialist nurse who will talk to you about your addiction, what your using and. What you want to do , if your wanting to cut down on your use of drugs or get off then conokuwtkey and then they will ask you if you feel you want to try maintenances, then they refer you to the addiction doctor , this part can take up to another three weeks or so and if they decide you need and you agree you want to be on methadone they will give you your script at that appointment and you take it to chemist and get started , first dose is always atm most 30 ml as that’s all they can safely at first but you will Have a nurse or addictions specialist who you will see evenly couple of weeks and if you call them n tell them it’s not holding you they can put it up at 10 mg every 4 days at most, Tuesday is normally the scripts are done so if you tell your nurse on the Thursday it’s but holding you you will normally why your new dose the next Tuesday, obviously as well as All this there’s groups and charities such as addaction who they prefer you to work with as I’m sure you know , methadone is all good but if your not going to work on the reasons behind your use it’s kind of pointless. Also if your I severe withdsawals when you first see them they can put you in to a detox but there’s very limited spaces , I was already in day 8 of withdrawal when I got my appointment so as painful as it was I just pushed through ,after my first appointment OJ day 8 of withdrawal I was told my appointment for the day is get the meth script would be 3 weeks away as they were so busy so you can imagine how depressing and scary that was. I sadly had a crisis about a week later and had a suicide attempt so was moved forward and seen quicker , I wildly suggest using it as a way to speed up process tho, certainly wasn’t what I was doing

Well im not an opiate addict, i suffer Severe Scoliosis, where correction surgery has a risk of being a vegetable so i choose pain, im on heavy daily opiates and being in canada with his opioid epidemic, my doctor clearly stated " No other doctor will prescribe you these meds at this level" which was just fkn wonderful to be told when i depend on this meds not to rip my head off, i wake up and practically roll out of bed because sittup up is just that painful unfortunately. But im on 400 mg morphine/daily among breakthrough oxy and ER dilaudid i dont take these for fun and games i do occasionally enjoy the buzz but its not the purpose of use, i also use cocaine to manage my pain levels to try and use less meds but in the end my condition is my fault, my dog was 18 years old and was healthy but was part german shepard so his hind legs were weak, and one day and i fucking told her over and over again before letting her take him for what she said was gonna be a " short walk" well 4 hours later she comes back telling me she cant get him to come upstairs that was the first day i ever had to carry him up 4 flights of stairs @ 135lbs. Before that he could do them slowly without an issue and he never recovered, and i wasnt ready to put him down so i took it upon myself for 8 months to carry him up and down, he could still walk no problem but up/down stairs wasnt an option and around month 4 i started eating codeine tablets that id been prescribed for probably 10 years prior so i had stacks of them, come month 8 id gone through every pill i saved and made the decision to go ahead with putting him down. I should have gone sooner but alass by the time i went to find out why i was in pain, i was diagnosed with severe scoliosis and given a high dose of painkillers that only got higher, and having recently been notified my doctor is retiring * somtime * no date within 5 years, im pretty fucked to say the least.i went out of my way to give heroin a go good stuff, took me 7 points ( smoked) to get relief and at 200 bucks a gram, isnt maintainable for me so im now facing possible methadone maintnance. I have a source whom sells it and did give it a go ( stupidly) i didnt know it blocks other meds from working so i suffered for a week till my meds worked after giving the methadone a go, but i took 40-60mg and after a good and fuck did i wait, 6ish hours it kicked in and i felt the effects, not near as pain relieveing but it worked for the wd i was feeling ( id only taken 1/4 my dose that day prior) so im collecting info on how to go about it to obtain a legal rx aswell as getting it without having to say im a junkie ( they test your blood levels here to see what level youre at or if you are lying to sell the methadone) and yeah this is my longest post on BL.
Well then ill assume you now have insight into my condition =p
~ zonxx

 

[Anthonysymington1967]

Firstly I’m sorry to hear your story and how much pain your in , it sickens me that doctors who were so willing to hand out pain pulse 10 years ago are now treating them like they were the plague and leaving there patients in agony , I don’t know what the rules are over in Canada but sounds like a methadone script would do you good , instead of alli these diff meds your on and trying to source other things from other places you would have one script and you would know it’s genuine stuff and where it’s from etc I’m just not sure if there would be a dosage they could give you that would truly help considering all your on. When you tried the morphine at 40 to 60 ml I think you said that kicked in after 6 hours, did it immediately block all your other opiates? I know methadone does have a blocking part to it which is why it’s good at stopping ppl using heroin for example and other opiates but I’ve read the dose has got to be at least 60 plus and I didn’t think it would block everything that quick or maybe I’m mid reading your message. After stopping the methadone how long did it take for your meds to start working again? Again I don’t know the rules etc in Canada and I know you have to pay for your care where ad over here we get it free on the nhs which is a blessing but is there not a pain specialist you could see? Explain to him all the meds your on etc and see if there’s a plan he could come up with which will help, as insure you know there’s no medication that your going to be able to take that will replace all those other meds and stop your pain but there’s got to be a better way. I hope you can find some help. Sorry o couldn’t be of any more help but obviously the Laws and regulations in diff countries are so different, the fact that I’m the US and I’m Canada they would actually let people die cos they couldn’t afford to pay the health bills n don’t have insurance horrifies me, that just wouldn’t happen over here , even if you weren’t from here

 

[negrogesic]

I was once on 380mg of methadone a day (however for the bulk of the time I was on 240mg/day). It is one of my favorite opioids. It was not for chronic pain (it was for opioid addiction), and since I went to an expensive private clinic I was allowed to get as much as I wanted (I'm in the US).

Not addicted to opioids now, though I fool with them sometimes and do my best to not get nabbed by the monkey. When I went to Australia to live for a bit, i took a three months supply with me, but had to transition to local methadone providers, which was awful since the max they would give me was 180mg/day.

Personally, I think methadone is great at high doses.

 

[Anthonysymington1967]

I was once on 380mg of methadone a day (however for the bulk of the time I was on 240mg/day). It is one of my favorite opioids. It was not for chronic pain (it was for opioid addiction), and since I went to an expensive private clinic I was allowed to get as much as I wanted (I'm in the US).

Not addicted to opioids now, though I fool with them sometimes and do my best to not get nabbed by the monkey. When I went to Australia to live for a bit, i took a three months supply with me, but had to transition to local methadone providers, which was awful since the max they would give me was 180mg/day.

Personally, I think methadone is great at high doses.

It’s for opiate addiction I’m on it. When you were on methadone did you dabble on any other opiates at the same time? Did you get anything out of them? I know methadone blocks other opiates euphoria etc but I’ve read and heard that only starts at doses of 60 ml n above or methadone. What was your experience?

 

[negrogesic]

Even when I was using those massive doses I could still feel IV heroin if I recall correctly. In order to really use it effectively however I had to take a from methadone.

I don't see 30mg as really putting up a sufficient blockade. The only way is to test it, however be aware of additive respiratory depression.

 

[Anthonysymington1967]

Even when I was using those massive doses I could still feel IV heroin if I recall correctly. In order to really use it effectively however I had to take a from methadone.

I don't see 30mg as really putting up a sufficient blockade. The only way is to test it, however be aware of additive respiratory depression.

“I had to take a from methadone” ? Sorrry what’s that mean?

 

[negrogesic]

*"i had to take a break from methadone", is what i meant

 

[Anthonysymington1967]

Of I use to take 900 mg of DHC without a problem , haven’t used it for about two weeks and been on methadone 30 mg for about 9 day what dose DHC you reckon would be safe to start at with the meth? Was going to start at 300 mg and see how it went, you think that’s too much ?

 

[KS78]

300 mgs of DHC is equal to 30 mgs of morphine. If you already feel any euphoria from your methadone dose, I would start with 100 mgs of DHC just to be safer. If it's barely holding you, you could take higher a dose.

I went to a clinic in Essex for heroin withdrawal and I was put on 240 mgs of methadone for a while there. I know that it's stupid but I chased some heroin which I had brought with from Istanbul while I was on methadone. I can definitely say that I felt it pretty good and I was a high dose intravenous heroin and cocaine addict.

 

[Anthonysymington1967]

300 mgs of DHC is equal to 30 mgs of morphine. If you already feel any euphoria from your methadone dose, I would start with 100 mgs of DHC just to be safer. If it's barely holding you, you could take higher a dose.

I went to a clinic in Essex for heroin withdrawal and I was put on 240 mgs of methadone for a while there. I know that it's stupid but I chased some heroin which I had brought with from Istanbul while I was on methadone. I can definitely say that I felt it pretty good and I was high dose intravenous heroin and cocaine addict.

Ok will start smaller and take your advice mate, thanks , always better to be safe

 

[Anthonysymington1967]

Somebody with more experience can and should correct me if I am wrong. But... Methadone does not block other opioids. The reason "sweet spot" is needed for methadone to block other opioids is because, unlike buprenorphine, methadone blocks you from feeling high on the basis of raised tolerance, not receptor blockade per se. That is why much higher doses of methadone are needed in comparison to buprenorphine. Buprenorphine blocks other opioids because it binds (associates/dissociates) opioid receptors so tightly that there are not many opioids that can outcompete it in this Game of Chairs. Imagine that you have 100 receptors representing "the chairs". Then imagine further that in 8mg of buprenorphine there are 100 buprenorphine players. You take 8mg of buprenorphine and the game begins. Now you take 100mg of morphine and in your CNS there are now 100 morphine players. When morphine player/molecule tries to sit on receptors chair it is unable because buprenorphine player/molecule is just to fast, so buprenorphine occupies all the receptors and morphine players are blocked and have no effect. Now you decide to up the intake of morphine for 100mg so another morphine 100 players enter the game. Now it is 100 buprenorphine players vs 200 morphine players and 100 available chairs. Another round begins and because the speed that buprenorphine associates/dissociates - again all the chairs are filled with buprenorphine and morphine is blocked. Not only that, buprenorphine does not even want to leave the chair before another round. It sits on the receptor very, very, very, very long time. This is the real blockade.

On the other hand, although methadone is quicker than most other opioids it is not that much of a difference as with buprenorphine. So if you were to put 100 methadone players vs 100 buprenorphine players buprenorphine would win the game. That's the reason why you would get precipitated withdrawal if you took buprenorphine while on methadone. And why you need to taper down to 30mg of methadone and then wait 3-4 days to start transition to buprenorphine. There has to be enough available seats/receptors for buprenorphine to come and sit without throwing out methadone players from receptors. Methadone players are really tough guys and they activate receptor almost fully. They are full agonist.


So how methadone blocks another opioids? Firstly it does have more affinity for receptors than lets say morphine. But the difference is not that big so morphine can still take hold of receptors if the numbers are right. With enough morphine trying to race to the receptor it will win the game and sit on it. That is why for the methadone to block receptors it must be taken in large quantities. So basically for methadone to be able to make morphine intake useless, methadone must be titrated to high enough level so that the tolerance will prevent normal or higher than normal doses of morphine from "working". That is why methadone is given in high amount. if it was given in lower amounts user with a high tolerance could easily "break through". But when you saturate receptors with methadone in doses above 100mg tolerance is driven so high that person would sooner OD than break through methadone dose. That is the reason why 8mg of buprenorphine blocks opioids better than 50mg methadone. At the same time 50mg methadone is much more powerful dose in terms of analgesia and euphoria.

And that is the reason why 900 mg of DHC is negligible dose once you are titrated up to therapeutic dose of methadone which is in 80-120+ mg range. With methadone is really more a matter of tolerance than pure blocking due to higher affinity for opioid receptors. Even with 30mg methadone, unless you are metabolizing DHC more than usual person u will not get great result. For the amount of possible "gain" I would strongly advise against using on top of methadone. You are risking OD with small difference in opioid stimulation.

I hope this all made sense, and if I said wrong and possibly dangerous things I would like to be corrected.

Take care,
Soma

Point taken and I understood most of it , u will need to re read it a few times to take it all in. The more I read the more i am thinking it’s not worth the risk at all, thanks for taking time to reply to me