kokaino
Bluelighter
- Joined
- Sep 8, 2007
- Messages
- 2,941
Heroin may be a morphine prodrug but it isn't the same as Morphine. The effects of Heroin are vastly greater. The only real similarity in terms of effects is the heavy sedation. Heroin is more euphoric and provides more body warmth. I'd take Heroin over Morphine any day.
As far as Demerol goes, I never got much of a buzz from it. I took 250mg of it a few times and it never got me to where I wanted to be. Didn't provide that classic opioid feeling. Its a full synthetic so I never really expected it to be.
Heroin's effects are due to the fact that it converts to morphine. Heroin itself is a very weak mu-receptor ligand. 6-MAM play a very small role and that too is a morphine prodrug (it's eventually - actually pretty rapidly too - converted to morphine). The two are essentially one and the same. The only difference in their molecules is the acetyl groups on the heroin molecule - they sort of act as a propeller to drive morphine faster to the brain then morphine would on its own. This is due to higher lipid solubility, which is why it is 1.5-1.8x more potent than morphine.
Studies have shown addicts given both morphine and heroin, preferred both over other opioids tested (fentanyl, oxycodone, hydromorphone, and meperidine). But didn't differ between the two (morphine/heroin), but they were able to differ the rest from morphine/heroin.