Greets to all... first post here on bluelight (old hand on some other substance-related forums though).
Someone I know is well into their third 100mg purchase of MDPV at the moment, and although definitely overusing/sleep deprived is pretty OK at this point. He's really big into harm reduction though, and has access to certain meds like enalapril and atenolol for blood pressure and other cardiac symptoms, not to mention benzos, sedative/hypnotics, phenibut and other substances that suppress the tendency toward panic/anxiety in higher doses.
The worst this stuff has done is erode away a good deal of his self-control... it's very difficult to resist 'chasing' after effects for foolish lengths of time, not to mention it produces cravings starting a few hours after wearing off and lasting at least a day or two. I understand it's really nothing compared to meth or coke, but standalone/lacking perspective it can look bad to some people.
This guy has been dosing so far by initially mixing 100mg MDPV powder with 50-100ml of water and either administering it intranasally (repeated small amounts) via pump mist sprayer, or rectally in one or two larger doses. He hasn't done it rectally for a while now, as this can unpredictably slow absorption and draw the effects WAY out (particularly sleeplessness). So can too much intranasal use too, as it builds up a blood level eventually... but it's much more predictable and easier to control.
He did experience a bout of serious depression after the first 100mg was gone, but could have been contributed to by any number of a wide variety of factors.
Anyway, just wanted to say hello and report on this fellow's discoveries.