Mda or any analogues, like 6 -apb, could work first, since its longer lasting, but best to wait two hours in to introduce mdma to access how your feeling. While dosing multiple times does increase neurotoxicity, dosing it this way, more than likely, would make smoother verses dosing all at once causing a tense come up.
Overly tense comeups caused anxiety, muscle tightness, too much stress, and caused uncomfortableness. Not something you want when enjoying an empathogen.
Ive recently discovered smoking cannabis cbd , with no to very little thc, after the first dose, and before the second dose, seemed to greatly ease the comeup to the point was quite relaxed. After a lot of expirience with smoking thc on the comeup, a certain of THC,in a scale of 1-10, a 3 or above seemed make the experience lackluster.