Misc Long term effects of Diphenhydramine

[d1ahp]

A friend of mine died by overdosing on it.

I made the mistake of taking eight 25mg pills once because I didn't have any xanax and I thought I'd substitute. It was honestly one of the worst times of my life. To make matters worse I just got done smoking a blunt as it kicked in and it amplified all the shittiness I felt. Never again.

I did take 50mg of it for sleep for over a year, however, which at that dose it'd produce nothing but drowsiness. After doing some research on it I decided to quit taking it.

 

[stranger1187]

I have taken diphenhydramine & dimenhydrinate every night for 6+ years. Sometimes together, sometimes just one or the other. If it's both, normally I take 600 mg dimenhydrinate and 300+ diphenhydramine. If just diphen, I'd say avg is between 400-500 mg, sometimes up to 1000 mg, but almost never less than 400. I rarely take dimenhydrinate by itself anymore. What I have noticed, at least for me, is the dimenhydrinate is the harder of the two substances. I have also noticed that with dimenhydrinate, audible hallucinations are more common. I used to write a lot of them down. At one point during this seven year stretch, I would hear two voices say two different sentences at once. Always short sentences. I can't remember when and what was said but often times it would be intriguing. For one, that I could remember both the sentences. I would always be in front of my computer when it happened so sometimes I could write it down in time. I always am in front of my computer when I am not going to work, etc.

These substances, when combined with thc, work very well for me. I know this is not the case for most individuals. It helps if you are engaged in an activity when I am under the influence. I am a computer musician and my work only started to improve after I started using these substances daily. The amount of creative energy that seems to come with this could be unique to certain people, for all I know, which isn't much. What I can say is that if I did not make music I am almost positive I would not like the substances as much and would not have used remotely as much as I have. I have had slightly embarrassing moments such as if I have a large quantity of diphen in my pockets and it is spilling out as I am sitting down with others. I don't make it known that I use but have told everyone I'm close to (there are only a few lucky ones lol) that I do this, but don't do it in front of them or anything. I've been told I have a problem because I had like 80 diphen's in my pocket and they all fell out. I told him I would have a problem if I was planning on doing all of them at once, yeah.

I have zero regrets and still love the substances. I was told I would only live three years if I live this way, and that was 5 years ago. It is true I am caught up in my own little world, and I am a bit antisocial, and enjoy being alone, and love to make music. Perhaps it's that combination that helps me enjoy these substances as much as I do. I have done many other drugs, do I know whether they are destructive or beneficial. Meth for example is destructive. I look no different and don't have really any side effects I can pinpoint because I use these two substances. I will say I have my good days and bad days with these substances, and it may perhaps be healthier to use less often, but I haven't yet! I also am a bit active, I ride a mountain bike all over the place, do not own a car. I think truly music is my first addiction, and anything that enhances sonic perception and that has continued to do so for this long, is pretty awesome.

 

[bipolarAlcoholic22]

Hi,

Up until recently, I was a heavy abuser of Diphenhydramine (benadryl, nytol etc.) Without a doubt I was/am psycologically addicted to the high it gives you. My question is: what can be some of the long term negative side effects of diphenhydramine use (at doses between 750mg-2500mg). After my most recent use, I became so ill I lost nearly 15lbs in 10 days, with other strange effects such as crazy nightmares and hearing static (white noise) in my ears. The effects faded away over the next two weeks, but it scared me a fair bit, as I never experience that before.

Thanks,

Chris

I am bipolar and an alcoholic and i am trying to find anything that causes a high so i can enjoy a recreational drug without the recreation of drinking, even if it has a different effect as long as it is enjoyable. Also legally. Most of you guys seem to be heavy users of this stuff- I have just had my Amazon order delivered of DIPH today 25mg 4 pack and would like to talk about toleration to sedatives a bit but first there is a difference between slow release tablets and short life span of drugs. I think the ones that act in half an hour are the most recreational instead of having to wait for a build up in your system like antidepressants of today like sertraline. My question is - 1- if you are not tolerated what should be a therapeutic amount ? And It seems that addiction is only caused byt the fact that you have to keep increasing the dosage to keep the same satisfying effects?

Main question, firstly I talk to my general practitioner a lot or known as the DR.PHD.. and I have a very cautious mind on drugs bit is it possible to use this DIPH as a therapeutic sedative for long term without abusing it?

 

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[mysafehome01]

If I take more than 150mg I can't feel my arms. They feel totally disassociated from my body and it's fucking awful. I can't even imagine what it feels like to take the kind of doses you are taking.

Please stop, for fucks sake.

 

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[rave23]

I have been taking 50 mg at bedtime since 2008, and so far i am healthy and in good shape

 

[Oakstone]

I have been taking 50 mg at bedtime since 2008, and so far i am healthy and in good shape

Does it actually still work for you? I've heard stuff that diphenhydramine grows a tolerance incredibly fast, and after three days of ~50 mg a night, it didn't help people any more than a placebo.

 

[rave23]

Does it actually still work for you? I've heard stuff that diphenhydramine grows a tolerance incredibly fast, and after three days of ~50 mg a night, it didn't help people any more than a placebo.

Sure, it no longer knocks me out, but still makes me sleepy and helps me wind down, and makes sleep come easy. I prefer taking it over benzodiazepines for that purpose. The addiction potential is not there, but if you take it for a while and then stop taking it abruptly you will notice some time of readjustment.

 

[AJ97]

I personally dont know what the long term effects of doses that high are. I have taken large(200mg+) amounts of the stuff. a reccomended dose is 25- 50 mgs. At that level, it can produce EXTREME confusion (No one should take 200 mg or more and remember anything of what happened) After taking 3-5 25mg tabs, I often wake up unaware of what day it is. I also have been COMPLETELY unaware of my surroundings (sounds fun, but after a large amount of this stuff, and many other substances, i wound up in the ER, and when they asked me where i was I did not know. I think I told them i was in France.) This is not fun. No doubt i am somewhat addicted to this, I have difficulty sleeping, and since I have no Heath insurance, I'm not going to the doctor. Any one else have confusion/blackouts from 100mg+ doses? Cause I do.

I took about 80-90 tablets and if they were 25 my the time that's 2,000+mg that I took of Benadryl. I remember taking them and then feeling high and I remember maybe one or two minutes during the whole experience but I don't really remember anything like my dad walking in and (I assume freaking out) calling 911 but I woke up in the hospital the next morning. I was high thru the whole thing and they couldn't even trace it in my system when they tried to see what was wrong so I got away with "I don't know what happened because I can't remember anything"
I usually only take about 10-20 pills to get high so I don't recommend taking more than 20. Fight the drowsiness and you'll feel the high instead of sleeping thru it.

 

[bingey]

hey you guys know there are actually good anti-histamines/anti-cholinergics out there? hydroxyzine is ok ,tripenelamine is some of the most addictive shit ever created once combo'ed with an opiate (as in t & blues) . still worthless without an opiate though and awfully hard on the veins (even the vials)

 

[cbwhit03]

The best potentiation combination I have found that really really works!!

#1.) Take a double-dose of NyQuil or DayQuil with Dextromethorphan. Wait 15 minutes, then proceed to step 2.
#2.) Take 50 mg. of Benadryl (diphenhydramine). Proceed to step 3.
#3.) Chew as many Tums acid removers as helps with your usual heartburn. For me, it is 2-3 Tums extra strength. Pop away your choice of opiates and potentiation is all taken care of.

 

[smoovie]

Although I agree that taking Benadryl at that level will have health implications your brain damage comments are grossly exaggerated and probably not true. I've done a considerable amount of research on this exact topic and I've never heard anything close to what you are claiming.

 

[smoovie]

Benadryl is one of the most commonly used meds to self medicate.

 

[smoovie]

Benadryl in medium doses (250 to 400) can act as a benzo substitute in emergency situations. The main differences I've found is a slight agitation on the come down and Benadryl takes longer to metabolize.

 

[morphine-dreams]

That high a dose of diphenhydramine can cause strong anticholinergic symptoms such as delirium and elevated heart rate. Not a good idea to use it as a benzo substitute IMO. Maybe 25-50mg but even then it'll probably only work for sedation.

 

[Cotcha Yankinov]

Some studies have shown somewhat recently that anticholinergics (specifically M1 antagonists) cause Alzheimer's. Studies of the elderly showed greatly increased risk of Alzheimer's in those taking anticholinergics like Benadryl, and animal studies have shown M1 antagonists cause accumulations of a plaque that builds up in the brain and causes Alzheimer's in animals given anticholinergics.

I would seriously re-think abusing Benadryl. Especially at those dosages...

 

[Mracid]

Brain damage ? really? the only brain damage possible is if he Depressed his Nervous system enough to kill neurons and that is not region per region thats a global cellular death due to global PNS and CSN Depression caused by overdose of an antimuscarinic agent. Other than that it can reduce the presence of patterns of action in your brain that protect/keep helthy neurons. Making your brain's lifetime to be lower. More chance of altzeimer, parkinson, even glaucoma. Not as harmful as DXM or other NMDA antagonists or Meth on brain cells but still really bad for their lifetime on a global level. Meaning that over the course of a lifetime DPH can kill more Neurons than other drugs but can't acuetly do it.

Solutions to relieve some symtoms. Try supplementing on Acetylcholine and mabe try noopept. Those should be good to help restabilize your Acetylcholine system and are both endogenous, so nothing more than supplements.

 

[rave23]

Benadryl in medium doses (250 to 400) can act as a benzo substitute in emergency situations. The main differences I've found is a slight agitation on the come down and Benadryl takes longer to metabolize.

This is absolutely wrong. An antihistamine will not substitute for a benzodiazepine.

 

[smoovie]

Substitute was probably a poor choice of words on my part. I absolutely do not recommend it as a benzo substitute but when you have no other choice and are without your benzo script for a short period of time a few Benadryl might help you relax just a bit. They won't do you any harm and might lower your anxiety and get some rest. If you are having severe symptoms and cannot get your benzo prescription refilled you should probably go to the ER.
I'm not an advocate for self-medication but sometimes a patient will lose pills and most docs will not refill a benzo script early so I offered this suggestion.