gingerbaker
Bluelighter
- Joined
- Dec 3, 2013
- Messages
- 69
I've read from a few sources that cayenne, black pepper and tumeric can potentiate the effects of Kratom. I can't find ANY pharmacokinetic information on Kratom and have no idea how it is metabolized. Also, I have no idea if it acts as a pro-drug wherein the 7OHM is actually an alkaloid that is absorbed directly or if it is a metabolite. That μ effect is what I'm after (for analgesia) and I'm curious how/why Kratom would be potentiated by the aforementioned substances.
I've also heard that NMDA antagonists are good potentiators, but it's my understanding that Kratom already contains an alkaloid with NMDA antagonist activity (although un-competitive if I remember correctly) so would something like Cat's Claw have a ligand with stronger affinity?
Why would a significant amount of people claim that tumeric, cayenne and black pepper potentiate the experience? Would it be due to enzymatic inhibition or something BA-wise because of pH or some other direct effect on the GI?
Thanks!
I've also heard that NMDA antagonists are good potentiators, but it's my understanding that Kratom already contains an alkaloid with NMDA antagonist activity (although un-competitive if I remember correctly) so would something like Cat's Claw have a ligand with stronger affinity?
Why would a significant amount of people claim that tumeric, cayenne and black pepper potentiate the experience? Would it be due to enzymatic inhibition or something BA-wise because of pH or some other direct effect on the GI?
Thanks!