FlawedByDesign
Bluelighter
- Joined
- Apr 4, 2009
- Messages
- 1,894
Hey, to any mods or more knowledgable people on here:
Does Kratom have proven negative effects on serotonin or proven long term negative effects overall as far as we know??
Does not seem to mess with serotonin enough to cause any down regulation-type effects like MDMA and friends but it does have some effect:
“Results suggest that both descending noradrenergic and serotonergic systems are involved in the antinociceptive activity of supraspinally administered mitragynine on the mechanical noxious stimulation, while the descending noradrenergic system predominantly contributes to the effect of supraspinal mitragynine on the thermal noxious stimulation.”
https://www.ncbi.nlm.nih.gov/m/pubmed/8982722/
That being said I am noticeably less depressed during Kratom withdrawal compared to even mild opioid w/d so it’s by far the lesser evil in my book.
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