Question about kratom: My sister takes methadone (about 40 mgs as needed) about 5 times a week (for her severe headaches due to a neck injury,) as well as 2mgs. Klonopin twice daily for anxiety and Ambien for insomnia. I want to be clear that she doesn't mix these things all at once, but she does take all of them on a pretty regular basis. Anyway, she wanted to try Kratom, but didn't know if it would work due to methadone's cross -tolerance with opiates/opiate-like drugs. She had taken her methadone dose at about 10 last night, and today was feeling particularly anxious amd depressed. So even though (as mentioned before) she doesn't typically combine drugs, today she took a 2mg Klonopin and smoked a bowl. She had the notorious munchies, and took a trip up to the convenience store; they sold Kratom, and she bought a 4 pack of Maeng-Da Organic Krarom, as well as one of those "Zen" shots which supposedly has Kratom in in. She took the whole shot and took 2 pills. She says she feels very relaxed and heavily buzzed, and and I would say that it was because of the weed and the Klonopin. However, she said that she felt an opiate-like high as well (and it can't be from the methadone, as it wore off this morning). Therefore she thinks that the methadone did not have a cross tolerance with the Kratom. It could be the weed/ Klonopin combo, or just placebo effect. I know there's no way to know, since for some, weed+Xanax by itself causes an opiate-like high, but I just want some opinions/ analysis...
I have no knowledge of Methadone at all, and only a little bit of knowledge of Ambien having taken it a bunch of times years ago but I didn't like the effect, felt it knocked me out too much....but I have lots of knowledge about Klonopin, Kratom and Weed.
Not sure exactly whether you are asking if the combo is safe or are you asking why she felt an opiate high???
If it's the latter....yes, I think Kratom is what gave her the opioid high plus maybe some left over Methadone from the half life because weed HEAVILY potentiates Kratom and increases the opioid high and I would GUESS that weed also potentiates Methadone but I can't be sure.
Then Klonopin potentiates most Opiates so I'd ASSUME it potentiates Methadone, but from personal experience I feel that it does NOT really potentiate Kratom so much in the sense that it eliminates most of Kratom's stimulant properties.
However, I think I WOULD say it SLIGHTLY potentiates the OPIOID/Downer side of Kratom...just a little....but I prefer not to take Klonopin when I'm on Kratom cause I like the stimulant effect.
Then you didn't say she took Ambien...but DEFINITELY Klonopin and Methadone potentiate Ambien...to the point that that COULD be a VERY unsafe combo if taken in large dosages....possibly fatal....
In the end...she's taking a LOT of drugs that potentiate eachother...so no shit she's going to feel high lol!!!!
But leaving out the methadone the combo of Kratom, Klonopin and weed is DEFINITELY a safe and very fun combo and nothing to worry about.
Even with the Methadone so long as the Klonopin dosage is low enough it's probably safe.
I don't understand exactly how Methadone and Kratom work together though so that is a question for someone who understands this stuff better.
It's the CNS depressants of Methadone, Ambien and Klonopin which she needs to be careful not to combine in large dosages.
Kratom is not known to be a serious CNS depressant and almost everyone who has ever done it agrees it does NOT depress breathing (at least PLAIN LEAF...extracts who knows....).
So I don't think it matters how much Kratom, weed and hopefully a moderate dose of Klonopin she combines (2mgs sounds fine).....but be careful with the other stuff.
Her opioid high is probably the combo of Kratom's downer effect partially stimulated by the Klonopin with the stimulant side suppressed by it however in combo with weed potentiating the Kratom and possibly a small amount of methadone left over as well....sounds like a nice mild opioid/benzo/weed cocktail that would give almost anyone a nice high.