- Conversely I'm attempting to put perspective on the nature and dose of meth use where its effects become chronically neuro-toxic.
Understanding the relationship between the molecular mechanisms underlying neurotoxicity of high-dose methamphetamine (METH) and related clinical manifestations is imperative for providing more effective treatments for human METH users. This article provides an overview of clinical...
jpet.aspetjournals.org
Working my way through this paper (unlocked):
"Neurotoxicity can be more broadly defined as a permanent or reversible adverse effect of a substance on neuronal structure or function (definition used by Environment Protection Agency for regulatory purposes), causing loss of neuronal components, loss of entire neuron, histological signs of neuronal damage, and/or behavioral abnormalities. Consequently, throughout this review, we include under this term neuronal degeneration/damage and also alterations in neuronal structure, morphology and function"
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12 on it's getting relevant.
"Sensitization to METH psychosis could be functionally related to neurotoxicity because psychiatric symptoms correlated inversely with DAT density in the striatum and PFC (Sekine et al., 2003)"
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25
"only a few compounds were able to attenuate METH neurotoxicity when administered after METH binge, namely DA uptake inhibitors, nicotinic receptor ligand lobeline (Eyerman and Yamamoto, 2005), and trophic factors (e.g. GDNF) (Cass et al., 2000); they are potential candidates for treatment of cognitive impairments in METHThis article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on June 19, 2017 as DOI: 10.1124/jpet.116.238501 at ASPET Journals on June 21, 2017 jpet.aspetjournals.org Downloaded from JPET #238501 31 dependent patients"
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30.
"there is evidence that electroconvulsive shock restores object-related memory in mice in a chronic METH paradigm (Chao et al., 2012). A separate group has shown that cognitive training may remediate some of the executive impairments in human METH users"
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- Mostly examines toxicity in short-term and high-dose subjects/animal-models.
Mechanism of toxicity = induction of neural hyper-excitation, associated oxidative stress, etc.
Kind of interesting but doesn't allude to anything in relation to long term use being neuro-protective or neuro-toxic.