I aquired a 1 gram vial of ketamine last Saturday. It was the first time I had used ketamine since 1999 before it became illegal. I stopped using it back then because the last few times I used it I had very bad experiences.
I had also never IVed it before, but in the past two years I only IV powdered drugs after becoming addicted to heroin and becoming addicted to the rush or IVing drugs.
At any rate, I started out with 10mgs. I found the experience to be very similar to snorting a 50-100mg dose. However the effects only last for about 15 minutes as oppossed ot an hour if you snort it. Although the higher the dose you use, the longer the effects will last.
During the week I kept increasing the doses. At about 25mgs, the effects of IV ketamine are much more psychedelic than simply dissociative as with snorting it. The experiences are very profound, but also very enlightening in the classical psychedelic way.
I injected it daily from Saturday until this past Friday every day. You build up a tolerance to it rather quickly and require more, but you also get more traditional psychedelic effects that offset the tolerance as you increase your doses.
At above 30mgs, you should be able to experience synaethasia along with mind blowing profound thoughts about reality and life.
My experiences were very rewarding and my setting would be me sitting in my room closing my eyes listening to music. As my doses increased during the week, I would become completely assorbed into the music and thoughts and everything would kind of melt together.
At 50mgs you being to experience COMPLETE synaesthasia when you close your eyes and simply lay down. You will "feel" the music, "see" the music and essentially transcend in a way much unlike simply snorting even a high dose of it.
My last dose on Friday was my last 100mgs (this should give you an idication that I was often using doses back to back during the week). The effects lasted for 45 minutes. I simply layed on the floor with my eyes closed and let the music envelope me.
I can't see the experience of IVing high doses of ketamine in a social setting because you become completely trapped in your own mind. And if you think moving around is difficult on a snorted dose of ketamine, IVing it also has a profound anaesthetic effect where you can't talk or comprehend "reality" anyways.
And as for having a trip sitter to remove the needle, I have to disagree. I was always able to count to 15-30 (a habit I developed by the time I was using up to half a gram of extremely pure heroin a day and that concerned about losing even a single milligram from the blood that would leak out of the injection spot) before removing the needle. This is also a good idea because the ketamine will burn as it escapes your vein. The effects start kicking in but not before I'm able to put an alcohol wipe over the injection spot, put the needle down, close my eyes and lay down. Although the effects come on quickly, it takes about a full minute before you're completely anaesthetized.
Another thing to consider is that your skin will turn pale after IVing ketamine and although the mental effects may be gone, some of the anaesthetic effects will last for up to two hours and you probably won't be walking straight. As well, even using sterile alcohol pads, you'll have bright red dots where you injected the ketamine as if you injected cocaine and unlike you injected heroin (heroin really leaves no visable marks unless you bruise easily or inject often). The marks take about 2-3 days to disappear.
My body also ached every day after injecting ketamine. I never got this effect from snorting ketamine and I don't know the cause of it. Ibuprofen got rid of the aches, but it's something to take into consideration. However after two days I felt completely normal again.
As for people saying to only inject liquid ketamine from the vial, again, I have to disagree. Powdered ketamine breaks down in water with only a minimal amount of stiring. You use a cotton filter. I've injected heroin, cocaine, oxycontin, and adderall over the past two years without any bad noticable effects as far as my veins or overall health go. There shouldn't be any impurities in ketamine anyways, and if there are and you're not intending to use regularly, a filter will certainly get rid of enough of them that they won't cause any problems so long as you are using sanitary techniques when injecting. Then again, I was using ketamine in the mid to late 90's when vials were extremely cheap and it was completely unheard of to cut ketamine, so maybe things are different now and impurities are a concern. But otherwise the only impurity in cooked ketamine should be saline which is also water soluable and safe to inject anyways.
If you are going to inject powdered ketamine, make sure to use a sterile saline solution or bottled water. Never use tap water when IVing or IMing any drug.
If you've read any articles suggesting that ketamine can help cure opiate addiction, the key is that the ketamine is used in a therapuetic session with a therapist. A weeks worth of ketamine has done nothing to stop my insatiable urge to use opiates (although no, I haven't used opiates regularly for some several months now, however the cravings are still there and have infact intensified with the change of the season, the days getting shorter and myself becoming depressed as a result).
Finally I take Depakote and occassionally Abilify to treat bipolar disorder and did not notice that there was any interaction between these drugs and my use of ketamine.