N&PD Moderators: Skorpio | thegreenhand
why is it that you can't come off the prescribed benzos because they're not a cure and you were prescribed them for a (remaining) disorder, as opposed to "irreversible brain changes"? fuck that.
err, why is the inability to comfortably come off of the drug that was prescribed out of necessity -- a drug that treats symptoms as opposed to curing -- automatically attributed to changes in the CNS caused by the drug as opposed to the state of the CNS that originally prompted the drug's use? fuckthat.I dont understand what you are saying here. Please re phrase
err, why is the inability to comfortably come off of the drug that was prescribed out of necessity -- a drug that treats symptoms as opposed to curing -- automatically attributed to changes in the CNS caused by the drug as opposed to the state of the CNS that originally prompted the drug's use? fuckthat.
Not all patients respond to other treatments, such as seroquel buspar prosac etc...
I don't think that we've yet developed an anxiolytic medication that retains efficacy over the long term with daily use.
ebola
It is hypothesized that GABA(A) binding sites in the nucleus accumbens form part of the sequence of events that is triggered by clonidine in an alpha2-adrenergic-specific manner and that ultimately results in a decreased release of dopamine in the nucleus accumbens.
*puts white coat on and funny plague protecting beak*
If you respond well to MDMA, you may find the SSRI crew could help
But, yeah, blunt as hell. The problem is the amnestic/sedatory effects blah blah. But this apparent resistance in the anxiolytic domain is one (of many) reason(s) the GABRA2/3 subunits are attracting a bit of pharma attention.
At this point, get little but anxiolysis from daily low-dose clonaz. Xanax I can go weeks/months without using.
There is a wide range of substances that will make the withdrawal much easier, provided you don't take them long enough to get addicted to them. Pregabalin, clonidine, trazodone, mirtazapine, hydroxyzine, benzatropine, baclofen etc., none of those interact with GABA_a receptors so you can use them to manage w/d symptoms.
Many people have come off high-dose/long-term benzo use without significant protracted withdrawal symptoms. I think if you follow an EXTREMELY slow taper plan, perhaps taking place over a year or more, you could successfully be benzo-free without severe PAWS.
There has also been some success using flumazenil (a benzo antagonist) AFTER you have tapered off of benzos. It is hypothesized to "reset" your GABAa receptors, allowing them to function normally (or more normal) in the absence of benzos.
Flumazenil in treatment of protracted benzo withdrawals: http://www.springerlink.com/content/2vpf562teffglej5/fulltext.pdf?MUD=MP
Here is a nice paper explaining the neuroadaptation associated with long-term Benzo dependence:
It can be accessed free at PubMed http://www.ncbi.nlm.nih.gov/pubmed/22536226