the safest way to clear out constipation for me personally was to take a daily dose of doccusate sodium and dulcolax before i went to bed. i'd take 4 caps of the doccusate and 2 of the dulcolax. now this is a terrible, terrible way of managing opiate induced constipation, however i kept on forgetting to stock up on lactulose (which comes in later in this) and had to do this several times.
when things got really dire (aka when i'd run out of laxatives, which happens from time to time), i'd use a fleet enema. they are weird fuckers i'll give you that, as i never really knew when they'd start working, but they would flush me out real good eventually. word of warning though - DON'T HOLD THEM IN FOR LONGER THAN AN HOUR - if they are the ones which contain phosphate i believe, as that can start causing electrolyte imbalances which is essentially another problem added to heap of shit you're trying to clear already. i had a splitting headache for the next couple of days after holding one in for about two hours. if an hour has passed and nothing, it's time to try and expel as much of that fleet enema that you can and get to a doctor. (i don't condone this, but personally if an hour had passed i would fill up the enema bottle with filtered water and squeeze it up there again and again). shove a glycerin suppository up there too, as your rectum could quite literally need that extra push which the fleet enema unfortunately doesn't give and get ready for the crap of a lifetime. - note this was when i had been backed up for about 10 days. i actually usually found that at this point the thing giving me real issues was that my sphincter muscles just would not relax (a bit graphic here - but i could feel how tense it was, so, lubed up a finger and hey presto was hellish. i'd usually take a warm epsom salt bath adding more and more salt to around my anus area until i felt the urge to go, and go i did eventually) yes, i've had to do the manual evacuation several times before and let me tell you it's highly unpleasant. i must have suffered from multiple bowel obstructions during my opiate abuse times as i tried to pass stool the size of footballs several times that i had to break up piece by piece, and let me tell you manually disimpacting them is fucking ego shattering, not to mention horrifically painful despite being doped up, slow and humiliating. not to mention the horrific haemorrhoids and anal fissures you suffer with on a daily basis too.
you really need to take care of your bowels when you're on opiates for a long period of time because the constipation is no fun whatsoever. it also starts to ruin the high of the opiates as you're constantly worried about your colon exploding. my best advice to you is that if you're going to be using opiates for a long term period start taking lactulose now, and never ever run out. it was my best friend, it doesn't stop being effective (apart from when you've forgotten to take it cause you're in an opiate and benzo induced stupor 24/7) and isn't harmful unlike so many of the other laxatives out there that are. 10mL at each meal should suffice, but when i was blocked up hardcore i'd swig it down - lots of discomfort, cramping etc for the next day or so, but it would clear me out sharpish even when taking opiates ontop. how safe that was i have no idea, but it worked miracles. keep up a healthy diet (i know it's really fucking difficult) but honestly, if you do, you'll be so grateful in the long run. the constipation was what eventually ruined opiates for me - but also scared the hell out of me. fuck the respiratory depression due to taking copious amounts of oxycodone and xanax, the constipation was the scariest in the end. i just can't imagine exploding inside out.
now this i don't recommend whatsoever, but it helped enormously for a short lived while: 40mg of d-amphetamine, 100mg of tetrazepam, 2 strong double espressos, a pint of water, and a cigarette. KABOOM. - that only helped for a little while though, became practically useless after a while and just will divulge you into an amphetamine and benzo addiction ontop of what you're already suffering - you don't need that whatsoever. (if i didn't use the tetrazepam it would be like shitting rocks, it's quite a potent muscle relaxant for the sphincter!).