Opioids How do I potentiate Morphine

[DaytonaGreg]

Actually, come to think of it... Carisoprodol (SOMA) is the only thing I can say categorically potentiates my Opiate high massively. It seems to work completely across the board for all Opiates that I have experience with, barring those with an *asterix* in front of them (Codeine, Dihydrocodeine, Oxycodone, *Morphine, *Diamorphine, Poppy Pod Tea, Tramadol, *Pethidine, *Kratom, *Bupenorphine, Hydrocodone, *Fentanyl)

Just be careful about mixing Opiods + Benzos (Xanax, Valium) + SOMA.
The Pain Management folks call those 3 the “TRIAD OF DEATH” if you take all 3 together (depending on the dosage).
My doctors stopped prescribing Soma and would not allow me to take Xanax (from Family Doctor) anymore. Too many patients were dying (stopped breathing) because it just depressed your whole system.
I can take the opioid but not the other medications with it. The only exception was for Flexeril (muscle relaxer). I could take that with opioid if needed (but NOT Carisoprodol, which is generic “Soma”).
My personal experience tells me that you should avoid the TRIAD (Opioid+Benzo+Soma) if you can AND ALSO try not to add OTHER STUFF like Benadryl (antihistamine) or alcohol.
When you start piling on chemicals & depressants at night (or whenever) your breathing slows dramatically, AND if you’re not careful you might not wake up.
I say this only hoping everyone STAYS SAFE & ALIVE. I know pain sucks. I’ve been fighting it 20+ years. Peace.

 

[ImthatMFer]

Take a Tagamet (acid reducer) or 2 one hr b4 dosing this will keep the supposed 30% of your dose from being by acids in your gut.
That n Benadryl as someone stated earlier I know for a fact n you’ll feel the difference.
Any antihistamines usually potentiate opioids if you can get some gabapentin that’ll help as well

 

[papercuts]

Take a Tagamet (acid reducer) or 2 one hr b4 dosing this will keep the supposed 30% of your dose from being by acids in your gut.
That n Benadryl as someone stated earlier I know for a fact n you’ll feel the difference.
Any antihistamines usually potentiate opioids if you can get some gabapentin that’ll help as well

Taking an acid reducer within two hours of gabapentin reduces gabapentin's absorbtion, but they say taking gabs half an hour after oral opiates is a potentiator.

I had my opiate a short while ago, had gabs earlier too, but I'm having hydroxyzine with it today, another potentiator as well as good in wds it's soothing on it's own, opiates are just nice with it. It's another antihistamine I think, so just chucking in my penny's worth.
Cyclizine is another antihistamine that might not potentiate directly, but if you feel sick with your opiates, it solves that, I don't know if it's an opiate itself, it has addiction warnings all over the bottle.
Antihistamines ought to help with itching of course too, that's good if you're trying to hide it, just don't overdo them or you'll sleep through it, haha.

Got some ammo haze here somewhere to keep me awake or gabs snorted are more stimulant.

 

[TheUltimateFixx]

Grapefruit juice. Just drink a small glass alongside your morphine administration.

 

[Jabberwocky]

Please elaborate...

Are you talking about plugging them by any chance?


I can't afford to buy any bud

I took some Diphenhydramine and Pregabalin.

I took 300 mg of Morphine tabs with 900 mg Pregabalin and 50 mg of Diphenhydramine and I'm still pretty high. That was about 10 hours ago...

Gabapentinoids like pregabalin and gabapentin enhance the analgesic effects of morphine. Apparently they also enhance the other effects as well.

 

[Jabberwocky]

Grapefruit juice. Just drink a small glass alongside your morphine administration.

That's because grapefruit juice inhibits cytochrome 450 CYP3A4. But you could also just take some quercetin.

The only problem is CYP3A4 is the cytochrome p450 enzyme responsible for metabolizing. Lots of drugs, not just morphine. So you could set yourself up for a drug accumulation or overdose. For instance, the blood thinner warfarin is metabolized in part by CYP3A4. If CYP3A4 is inhibited, warfarin levels will increase with recurring administration leading to an increased INR and possibility of major bleeds or stroke.

And don't use any Cialis. Sildenafil is metabolized by CYP3A4, and some individuals have experienced an increase of 260% in the serum after drinking one glass of juice. You can end up with priapism where your dick will not get soft, which is the medical emergency because gangrene could set in and you could lose your dick.

 

[papercuts]

That's because grapefruit juice inhibits cytochrome 450 CYP3A4. But you could also just take some quercetin.

The only problem is CYP3A4 is the cytochrome p450 enzyme responsible for metabolizing. Lots of drugs, not just morphine. So you could set yourself up for a drug accumulation or overdose. For instance, the blood thinner warfarin is metabolized in part by CYP3A4. If CYP3A4 is inhibited, warfarin levels will increase with recurring administration leading to an increased INR and possibility of major bleeds or stroke.

And don't use any Cialis. Sildenafil is metabolized by CYP3A4, and some individuals have experienced an increase of 260% in the serum after drinking one glass of juice. You can end up with priapism where your dick will not get soft, which is the medical emergency because gangrene could set in and you could lose your dick.

Is quercetin the really bitter chemical that is used against malaria? Makes your hair fall out? Then for a finale makes your dick fall off,

The same cytochrome 450 CYP3A4 pathway is used by cannabis, the body prioritises removing THC over removing morphine so even weed potentiates that way. As does kratom and the berberine contained in goldenseal, all inhibit the cytochrome 450 CYP3A4 pathway and make morphine stay in your system longer. I don't think it affects the peak concentrations, just slows down the half lives so it stays in your system longer, I'm not sure.

I had half a tin of grapefruit yesterday and slept really badly all night, but nothing fell off thankfully.

 

[leenonamous]

Hello Bluelighters

How do I potentiate Morphine tablets? I have Andipharm 10 mg Morphgesic SR ... I ground them up as much as possible and put the dust in a small amount of tea (not a hot cup of tea) and swallowed the dust down about 45 minutes ago. About 30 minutes before that l took 900 mg of Pregabalin and 50 mg Diphenhydramine. Is there any better/safer methods to potentiate this drug?

Also, is crushing them into fine power enough to break the time release?

Thanks in advance.

Benzos always potentiate opiates for me. Especially in combination with pregabalin. Obviously you have to be careful depending on your tolerance.

 

[leenonamous]

Well they are more than likely going to be either Flualprazolam/Flubromazolam/Etizolam, unfortunately.

I have my genuine Diazepam to fall back on though...

Yea. You gotta be careful with repressed Xanax (Xanax with rc's). If you're going to go that route maybe try half (depending on your tolerance) and go from there.

 

[Jabberwocky]

Is quercetin the really bitter chemical that is used against malaria? Makes your hair fall out? Then for a finale makes your dick fall off,

The same cytochrome 450 CYP3A4 pathway is used by cannabis, the body prioritises removing THC over removing morphine so even weed potentiates that way. As does kratom and the berberine contained in goldenseal, all inhibit the cytochrome 450 CYP3A4 pathway and make morphine stay in your system longer. I don't think it affects the peak concentrations, just slows down the half lives so it stays in your system longer, I'm not sure.

I had half a tin of grapefruit yesterday and slept really badly all night, but nothing fell off thankfully.

No, you're thinking of quinine.

Quercetin is an antioxidant flavonoid.