I recently took a 1500microgram dose of LSD, and I completely second clocktower that the most important thing you could possible do is reagent test your stuff first before you embark. It will provide immense comfort to you on your trip if it goes bad that you have actually taken LSD and no anxiety will arise that it was something else. If your a smoker like I am, stock up on a few packs of cigarette as chainsmoking was my lifeline during a very hard patch of my trip. Benzos helped towards the end immensely and it would be insane to embark without them as they were literally a savior at the 10 hour mark (3mg Xanax). I also recommend an opiate, such as oxycontin or poppy pop tea, it helps transcend me into a meditative state. I had an ego death three hours in, then 2 hours of the most horrible paranoia I have experienced and the opiates helped me so much, I retreated into a dark space, candle lit and listed to Chopin after taking and I calmed down and experienced the magnificence of LSD. I actually recommend you have no commitments for at the very minimum 48 hours at a huge LSD dose as I was totally incapacitated for that time. So, I say, test your stuff and setting.