I've taken two doses of this so far; one attempt at 250mcg, another at 400mcg (give or take 50mcg).
Both trips were nice and had great visuals, I won't bore you with the details of the trips themselves.
I did want to mention the side effects/day after effects I have had;
- Vasoconstriction was noted on both attempts (shrunken penis, cold feet/hands).
- Muscle spasms (mostly in the legs). Leads to sore thighs the next day.
- Tongue tied/trouble forming sentences after peak
- Lasting visuals (ala HPPD) for days afterwards
- It causes me to itch post trip, and gives me feelings similar to begin bitten by mosquitos
- Headaches both while tripping and for days after dosing
- Feeling of begin drained for days after the trip, sleeping more than usual.
- Feelings of impending doom.
- Racing heart, with a worrying pain under the left arm and in the chest.
My ROA was nasal by the way, as my 25E came pre-prepped in a nasal spray bottle from a trusted friend.
Aside from first hand experience I want to add that I have seen many people consume this over the last two months. I know for sure it was 25e and not something else. All these users took it nasally as well.
I've seen both newbies and experienced users have freak outs on doses as low as 150mcg. I've also seen people constantly dose the stuff to the point where they had no effects other than stimulation. I've seen people dose it over an entire weekend to avoid sleeping. I obviously do not suggest anyone do this.
I highly advise anyone that plans on experimenting with this to proceed with lots of caution. I feel this substance is a bit damaging to the body/mind and given its ability to cause massive tolerance I don't plan on doing it very often. It doesn't feel safe at all to me.
One last note: every time I've smoked cannabis on this substance I've had it bring on lots of anxiety and panic attacks.