TurkeyRanch
Greenlighter
- Joined
- Jul 20, 2014
- Messages
- 30
My understanding is that it's possible -- any free state / bound state equilibrium reaches saturation at some concentration (see also, e.g., "100% humidity") -- but you've only saturated the highest-affinity receptors (5-ht1a, 5-ht2a, 5-ht6). Above that point you start to see more binding to secondary targets (5-ht1d, 5-ht5a, 5-ht2c, less so 5-ht2b, 5-ht7 and D3) which continues to change the experience. Of course, given that most people who do thumbprints report that the experience is very intense, but not really "insightful", it's possible you move from psychedelic to simply intoxicating.
Also, most doses are probably overestimated -- in the literature, even 80 micrograms is a pretty significant experience, but many people report that they take 200 regularly.
I am very much in agreement with you. LSD in high doses is similar to smoked DMT for me, very confusing, intense, and only partially of value. Ayahuasca seems to get you almost as high, but retains it's usefulness. It is not simply only "intoxicating" but the experience is so intense that I didn't glean much as far as lessons learned. Don't get me wrong, it was beautiful and terrifying, but I choose different substances or lower doses to bring back the lesson.