N&PD Moderators: Skorpio | thegreenhand
I'm not sure kappa receptors have much to do with hallucination, even if extreme agonism leads to hallucination indirectly. Which hallucinogens are kappa ligands? Even serotonin or NMDA are more likely candidates just based on the number of hallucinogens I can think of off the top of my head that act on those receptors and aren't kappa opioids at all.
But there are different kinds of opioid hallucination. Morphine and heroin give me closed eye visuals that are surreal and vivid with odd low color palettes. It's very dream-like.
Any effect from morphine/heroin would be/is mediated by mu-receptors, as I was trying to differentiate from the effect of k-receptors in my first post in this thread.
is most definitely dissociative due to NMDA antagonism.
Suboxone, especially when taken sublingually rather than snorted is pretty potently hallucinogenic for swim. Even much more so when combined with good weed. It feels for swim very anticholinergic and dreamy, possibly antihistaminic and is most definitely dissociative due to NMDA antagonism. It's the closest drug in feel swim has ever tried to DXM and reproduces much of its dissociative qualities, but is more visual and far less mental. The nod off, especially with weed is very powerful and euphoric, though can be much too much, during which swim has very vivid and continuous CEVs which are mostly picture and memory-like...dreamlike, just as with DXM, which only gives shapes and pictures, no random psychedelia like most psychedelics.
DXM is a stereoisomer of an opioid and has NMDA effects, I think it's also within reason, chemically, to suggest an NMDA antagonization.
High doses of morphine give me very vivid CEVs, and even mild OEVs. I am schizophrenic and have synaesthesia; I don't know if that plays a role.
Buprenorphine is a large substrate for a receptor, especially among non-peptide opioids and opiates. Very few are as big as buprenorphine, though of course several are. I think the large size in addition to correct sterics and maximized binding (for this stereochemistry) allows for it to bind very mildly, because the normal opioid moeities are still there, just one stereocenter changed. It is obviously not a very powerful NMDA antagonist, but SWIM feels a shadow of ketamine and dxm. Just a suggestion, no need to be offended.