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Gabapentinoids Gabapentin Megathread

Well, ten grams is a bit much to start, but it's more than enough to get a feel for it.

Good news too! Having to eat twelve pills for a threshold will slow you down, and it's best to "stagger" the doses anyway (for absorption).

ETA: and keep in mind that a big chunk of people who've tried it find it very sedating, and that might include you. So start low, la da da.

You asked about benzos, implying you're on them, and might not want to mix them right away or ever (in case you do get sleepy).
 
Na i was dissapointed getting only 100mg because I have to eat more whereas if I had a bigger dose it would save me money.
What is the duration & how long does it take to kick in?

Is it anything like Lyrica because I have had Lyrica in a massive dose cant remember how much but it felt like i was drunk i was literally bumping into walls when walking.

Ive also read a few reports of people getting seizures from Gabapentin.
 
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I haven't read of gabapentin use itself causing seizures. It's a pretty benign medication. The withdrawal from it if you become dependent might lower the seizure threshold, but using it doesn't seem to. Unlike pregabalin, where higher doses can cause a seizure. The subjective experience of pregabalin and gabapentin have a lot in common though.
 
toothpastedog said:
I haven't read of gabapentin use itself causing seizures. It's a pretty benign medication. The withdrawal from it if you become dependent might lower the seizure threshold, but using it doesn't seem to. Unlike pregabalin, where higher doses can cause a seizure. The subjective experience of pregabalin and gabapentin have a lot in common though.
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Type in google 'gabapentin seizures' and you will see lots of reports of people having seizures and not just from withdrawal.

On another note: I took 1200mg with 2mg Alprazolam three hours ago and feel a bit relaxed. Dont know if it made me more social as im not in a social situation.
 
I admit I haven't and probably won't do that search. Just look at the URLS to these stories, or at the ads on the page, and you'll get an idea. I think class-action lawyers copypasta random drugs and diseases to find clients.

Gabapentin and pregabalin are both anti-epilepsy, reviewed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114206/

A survey of epilepsy specialists in 2017: "Compared to the 2005 and 2001 surveys, there was increased preference for the use of levetiracetam and lamotrigine, and decreased preference for the use of phenytoin, gabapentin, phenobarbital and carbamazepine."

But then, high doses of lots of things might cause a seizure.

Haven't tried pregabalin/Lyrica, but my understanding is they fixed a lot of the kinetics problems. Meaning it's more potent. Otherwise same mechanism.

Your gabapentin experience would just be a bit milder than the pregabalin, and take three hours longer to happen. BUT it's whole lot cheaper, at least.

I don't know why food would come up. I don't get munchies or anything. You do not have to eat weird things with them, or anything at all.
 
It is hardly guaranteed, but a high enough dose probably could lower your seizure threshold. But that would be a massive dose, exponentially higher than what one would normally be tolerant to. Pregabalin gets into issues over 600mg, but gapabentin doesn't seem to get into particularly dangerous territory even at 10,000mg.

If one was already prone to seizures or has had them before, I'd suggest being caution just because it is the smart thing to do. But from what know about gabapentin it isn't a significant issue like it is with something like tramadol or pregabalin.
 
Yeah, Mr. Dob, these things don't cause seizures at any level, unless you mixed with other drugs or had a seizure disorder already. This includes gabapentin and pregabalin/Lyrica.

The exception is tiagebine, which is what you were taking when you had your seizures. Overdoses of that are associated with seizures. It works in a completely different way from gabapentin and pregabalin and benzos.



So:
Tiagebine OD: seizures maybe
Gabapentin OD: no seizures
Pregabalin OD: no seizures
Benzo OD: no seizures
Lamictal OD: no seizures
 
Thanks for the info ill be staying away from Gabapentin now.

Yeah Tiagabine was what caused my first seizure. I took alot of it because I didn't think they were kicking in.
 
It's a damn shame how quickly tolerance builds to this med. I make sure to take days off, but if I do it a few days in a row, I end up needing a ridiculous dose to get any kind of high. Like today, I've taken about 6,000mg, which is an insane dose. After I've taken a break for a week or so, I only need like, 2,500mg. How fucked up is that? Tolerance to gaba builds so damn fast! And I wish I could find a doc who'd be willing to give me a ketamine infusion for my nerve pain, but I doubt I could find one, and even if I could, at $300 or so a shot, there's no way on God's green earth I could afford it!
 
I totally agree, it really amazed me how tolerant I became so quickly to gabapentin. I went from needing only 800mg to get all the desired effect to 4g in a matter of weeks. Towards when I stopped needing to use gabapentin I was sometimes taking 20g a day. And I never used it frequently enough to become dependent or have to go through withdrawal, only tolerant. Never experienced anything quite so dramatic regarding tolerance, not even opioids.
 
Me neither. I've developed a massive tolerance, but I always skip enough days to avoid any withdrawals.
 
Do not snort them, awful burn, awful drip, awful taste and it does not do anything more than just swallowing it would, plus you have a heap of powder in the capsules and would end up with atleast 5 fat lines to do..
 
toothpastedog said:
I totally agree, it really amazed me how tolerant I became so quickly to gabapentin. I went from needing only 800mg to get all the desired effect to 4g in a matter of weeks. Towards when I stopped needing to use gabapentin I was sometimes taking 20g a day. And I never used it frequently enough to become dependent or have to go through withdrawal, only tolerant. Never experienced anything quite so dramatic regarding tolerance, not even opioids.
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Do you mean once a year, or how could you afford this?
 
Gabapentin has generic manufacturers now and is relatively cheap and being unscheduled, receiving multiple scripts wouldn't be overly difficult. I went through a similar dose escalation like Toothpastedog and while I didn't quite reach 20g I was way up there for 8-9 months and payed for it with a rather prolonged nasty withdrawal syndrome that cost me a pretty cool friend on this site. Although I wasn't using it at first and did have a years worth saved up or my habit would have been more conservative.

Point being it really does build tolerance insanely fast and I get more out of it by using it in week long spurts but I'm not using it for herpes zoster neuropathy or anything like that.
 
I was only taking those kind of insane doses/binges occassionally mind you. With insurance the stuff was super cheap, although I can't justify those kinds of doses any which way.
 
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Really. 20 grams of Gabapentin is insane. At those doses, is the high the same as on Pregabalin?
 
The high from that dose is essentially the same as a "more reasonable" dose of like 4g, only point of taking so much is tolerance. And even then the effects aren't particularly strong. I tend to prefer the effects of gabapentin to pregabalin though. Side effects of high doses of pregabalin were rather odd and uncomfortable (and high doses of pregabalin are more like at and over 900mg, not multiple grams), whereas I didn't notice any similar degree of uncomfortable side effects with those unreasonably high doses of gabapentin.
 
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