I'd just like to contribute something to this thread. A little more than a year ago, possibly even a little more, I started messing around with JWH-018 (my first trip into the RC world really). At first, the highs were incredible; better effects than weed, a fraction of the price, and it seemed like no bad effects on the body. I went through maybe 2-3 grams over a few months at first, and it seemed delightful. Then there came a time when I bought a large quantity of JWH to share with some friends. I ended up making a little money, or maybe even just breaking even, but I had maybe 3-5 grams of JWH-018 left at that point.
Over one week, I smoked all of that JWH-018 nonstop all day everyday, some days approaching a gram of material, in addition to typically having 1/8th or so of low-mid grade bud daily. One of these days, I decided to trip on acid, and since I was totally out of bud, I figured I'd smoke some JWH-018 to brighten up the trip. I ended up smoking through probably around 50mg+ in one setting with my terrible tripped-out judgement, and the next thing you know I was experiencing extreme heart palpitations, chest pain, and anxiety. Despite the fact that I was on LSD, this didn't TOTALLY freak me out, but I did spend perhaps 2 hours in a mild panic attack, and chugged around 7-10 bottles of water in this time. Eventually I calmed down, but thing still didn't seem right.
After that day, every time I would smoke weed or any cannabinoid, my heart would go off like crazy and the anxiety would make me regret even smoking. After a few months of this (mid you I'm a stoner, so I kept going at it despite the obvious anxiety and chest pain), I was having panic/anxiety attacks WITHOUT smoking, and it seemed like they got worse and worse for months. The anxiety got so bad for a few months that I became downright agoraphobic and was afraid to do the simplest tasks, like driving or going to school. I dropped out of school for a semester and became a total hermit. After maybe a little over 6 months of frequent chest pain, I began using opiates regularly to take away all the pain and anxiety, and I thought that it would really help. After a few more months, I went to see my family doctor, who gave me Paxil (an SSRI anti-depressant) and a tiny script of 0.25mg Xanax for my anxiety. The Xanax helped me greatly, but I ditched the Paxil, afraid of the side effects. I went to a shrink about a month later who was happy to let me go without the Paxil and give me the Xanax I really needed. I got started out at 0.5mg 3x daily. This worked wonders, but at this point in time, my opiate addiction was spiraling out of control.
Yet a few months more passed, and I went to see a local Suboxone doctor to try and get off the opiates [as I was up to a 60mg insufflated Opana (oxymorphone) habit, sometimes that dose all at once, sometimes smaller doses throughout the day adding up to over 60mg total, and of course I was also using whatever other opiates I could find, morphine, oxycodone, hydrocodone, and even methadone or Suboxone when desperate). The doctor at the sub clinic set me up with 8mg Suboxone 2x daily, a dose that was way more than I needed. They also required me to submit piss tests, go to NA, and spend $50 a week meeting with one of the clinic's therapists. I ended up devising a plan to use as little Sub as possible and quit on my own (and immediately got down to 2mg 2x daily, the 1mg 2x daily). After 2 weeks of being treat like shit and made to go through hell at the clinic, I left with my remaining script (maybe 10 8mg Subs) and decided to quit solo.
Nowadays I'm almost off of the Suboxone (down to 1-2mg a day, depending on the day), I still take 4 x 0.5mg Xanax a day, and I'm back to smoking weed without anxiety. Even without the Xanax, my anxiety levels are very low, but when I think back on all of this, my anxiety all started with that JWH-018 incident. It's a chemical that most younger people totally ignored the dangers of and wrote off as safe, and I'm certainly not the only person I know who developed problems because of it. So to anyone who finished reading this post, my advice to you is to be VERY careful with synthetic cannabinoids, ESPECIALLY the stronger full-agonist ones like JWH-018. They can really wreck your life if you treat them the same as bud.
I may well be on Xanax for a VERY long time due to the anxiety this chemical caused me by mistreating it. I also have a lifelong opiate addiction to wrestle with (which I am happily, but slowly conquering), and STILL get random chest pains/intense anxiety and paranoia sometimes, which never happened before I tried the JWH-018. I am worried that I may someday discover long-term physical damage from using this stuff, even though the physicals and doctor visits I've had have said I'm in perfect health. If not physical damage, this stuff at least caused me mental trauma in the form of anxiety and fear.